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Closed Access item Local modulation of the 5-HT release in the dorsal striatum of the rat: an in vivo microdialysis study

Authors:Abellán, M. Teresa
Martín-Ruiz, Raúl
Artigas, Francesc
Keywords:5-Hydroxytryptamine, 5-HT receptors, Acetylcholine, Dopamine, GABA, Glutamate
Issue Date:Dec-2000
Citation:European Neuropsychopharmacology 10 (6) : 455-62 (2000)
Abstract:Using in vivo microdialysis in freely moving rats, we examined the involvement of major striatal transmitters on the local modulation of the 5-HT release. Tetrodotoxin reduced the striatal 5-HT output to 15–20% of baseline. The selective 5-HT1B receptor agonist CP 93129 (50 μM) reduced (50%) and the 5-HT2A/2C receptor agonist DOI (1–100 μM) increased (220%) the 5-HT output. Neither GABA nor baclofen (100 nM–100 μM) altered the 5-HT output. The glutamate reuptake inhibitor l-trans-PDC (1–4 mM) raised 5-HT to 280% of baseline. This effect was not antagonized by the NMDA receptor antagonist MK-801 (0.5 mg/kg i.p.). Local MK-801 (10–100 μM) did not significantly alter the 5-HT output. Finally, neither carbachol (10–100 μM) nor quipirole (10 μM–1 mM) affected 5-HT. These data suggest that the striatal 5-HT release is influenced by local serotonergic and glutamatergic (but not GABAergic) inputs.
Publisher version (URL):http://dx.doi.org/10.1016/S0924-977X(00)00118-8
E-ISSNmetadata.dc.identifier.doi = DOI:1873-7862
Appears in Collections:(IIBB) Artículos

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