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Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/34721
Title: Local modulation of the 5-HT release in the dorsal striatum of the rat: an in vivo microdialysis study
Authors: Abellán, M. Teresa; Martín-Ruiz, Raúl; Artigas, Francesc
Keywords: 5-Hydroxytryptamine
5-HT receptors
Issue Date: Dec-2000
Publisher: Elsevier
Citation: European Neuropsychopharmacology 10 (6) : 455-62 (2000)
Abstract: Using in vivo microdialysis in freely moving rats, we examined the involvement of major striatal transmitters on the local modulation of the 5-HT release. Tetrodotoxin reduced the striatal 5-HT output to 15–20% of baseline. The selective 5-HT1B receptor agonist CP 93129 (50 μM) reduced (50%) and the 5-HT2A/2C receptor agonist DOI (1–100 μM) increased (220%) the 5-HT output. Neither GABA nor baclofen (100 nM–100 μM) altered the 5-HT output. The glutamate reuptake inhibitor l-trans-PDC (1–4 mM) raised 5-HT to 280% of baseline. This effect was not antagonized by the NMDA receptor antagonist MK-801 (0.5 mg/kg i.p.). Local MK-801 (10–100 μM) did not significantly alter the 5-HT output. Finally, neither carbachol (10–100 μM) nor quipirole (10 μM–1 mM) affected 5-HT. These data suggest that the striatal 5-HT release is influenced by local serotonergic and glutamatergic (but not GABAergic) inputs.
Publisher version (URL): http://dx.doi.org/10.1016/S0924-977X(00)00118-8
URI: http://hdl.handle.net/10261/34721
ISSN: 0924-977X
DOI: 10.1016/S0924-977X(00)00118-8
E-ISSN: 1873-7862
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