Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/34721
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Local modulation of the 5-HT release in the dorsal striatum of the rat: an in vivo microdialysis study |
Autor: | Abellán, M. Teresa; Martín-Ruiz, Raúl; Artigas, Francesc CSIC ORCID | Palabras clave: | 5-hydroxytryptamine 5-HT receptors Acetylcholine Dopamine GABA Glutamate |
Fecha de publicación: | dic-2000 | Editor: | Elsevier | Citación: | European Neuropsychopharmacology 10 (6) : 455-62 (2000) | Resumen: | Using in vivo microdialysis in freely moving rats, we examined the involvement of major striatal transmitters on the local modulation of the 5-HT release. Tetrodotoxin reduced the striatal 5-HT output to 15–20% of baseline. The selective 5-HT1B receptor agonist CP 93129 (50 μM) reduced (50%) and the 5-HT2A/2C receptor agonist DOI (1–100 μM) increased (220%) the 5-HT output. Neither GABA nor baclofen (100 nM–100 μM) altered the 5-HT output. The glutamate reuptake inhibitor l-trans-PDC (1–4 mM) raised 5-HT to 280% of baseline. This effect was not antagonized by the NMDA receptor antagonist MK-801 (0.5 mg/kg i.p.). Local MK-801 (10–100 μM) did not significantly alter the 5-HT output. Finally, neither carbachol (10–100 μM) nor quipirole (10 μM–1 mM) affected 5-HT. These data suggest that the striatal 5-HT release is influenced by local serotonergic and glutamatergic (but not GABAergic) inputs. | Versión del editor: | http://dx.doi.org/10.1016/S0924-977X(00)00118-8 | URI: | http://hdl.handle.net/10261/34721 | DOI: | 10.1016/S0924-977X(00)00118-8 | ISSN: | 0924-977X | E-ISSN: | 1873-7862 |
Aparece en las colecciones: | (IIBB) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
21
checked on 17-abr-2024
WEB OF SCIENCETM
Citations
20
checked on 21-feb-2024
Page view(s)
270
checked on 19-abr-2024
Download(s)
53
checked on 19-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.