Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/34680
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Title: Effects of acute olanzapine after sustained fluoxetine on extracellular monoamine levels in the rat medial prefrontal cortex
Authors: Amargós-Bosch, Mercè, Artigas, Francesc, Adell, Albert
Keywords: Medial prefrontal cortex
Fluoxetine
Olanzapine
Microdialysis
Osmotic minipump
Issue Date: 15-Jun-2005
Publisher: Elsevier
Abstract: The combination of selective serotonin reuptake inhibitors with atypical antipsychotic drugs exhibits beneficial effects in treatment-resistant depression. We investigated the effects of a 2-week treatment with a low fluoxetine dose (3 mg/kg per day) plus a single injection of olanzapine (3 mg/kg) on the dialysate concentration of noradrenaline, dopamine and serotonin (5-HT) in the medial prefrontal cortex of the rat. Chronic fluoxetine increased only 5-HT levels whereas single olanzapine administration increased the concentration of catecholamines and decreased that of 5-HT to a comparable extent in vehicle- and fluoxetine-treated rats. Therefore, it is possible that the therapeutic benefit of this pharmacological combination may not be associated to changes in the cortical concentration of monoamines, but to postsynaptic blockade of monoaminergic receptors.
Publisher version (URL): http://dx.doi.org/10.1016/j.ejphar.2005.05.004
URI: http://hdl.handle.net/10261/34680
ISSN: 0014-2999
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Citation: European Journal of Pharmacology 516 (3) : 235-238 (2005)
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