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Closed Access item Effects of acute olanzapine after sustained fluoxetine on extracellular monoamine levels in the rat medial prefrontal cortex

Authors:Amargós-Bosch, Mercè
Artigas, Francesc
Adell, Albert
Keywords:Medial prefrontal cortex, Fluoxetine, Olanzapine, Microdialysis, Osmotic minipump
Issue Date:15-Jun-2005
Citation:European Journal of Pharmacology 516 (3) : 235-238 (2005)
Abstract:The combination of selective serotonin reuptake inhibitors with atypical antipsychotic drugs exhibits beneficial effects in treatment-resistant depression. We investigated the effects of a 2-week treatment with a low fluoxetine dose (3 mg/kg per day) plus a single injection of olanzapine (3 mg/kg) on the dialysate concentration of noradrenaline, dopamine and serotonin (5-HT) in the medial prefrontal cortex of the rat. Chronic fluoxetine increased only 5-HT levels whereas single olanzapine administration increased the concentration of catecholamines and decreased that of 5-HT to a comparable extent in vehicle- and fluoxetine-treated rats. Therefore, it is possible that the therapeutic benefit of this pharmacological combination may not be associated to changes in the cortical concentration of monoamines, but to postsynaptic blockade of monoaminergic receptors.
Publisher version (URL):http://dx.doi.org/10.1016/j.ejphar.2005.05.004
E-ISSNmetadata.dc.identifier.doi = DOI:1879-0712
Appears in Collections:(IIBB) Artículos

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