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dc.contributor.authorSánchez-Moreno, Concepción-
dc.contributor.authorCano, M. Pilar-
dc.contributor.authorAncos, Begoña de-
dc.contributor.authorPlaza, Lucía-
dc.contributor.authorOlmedilla Alonso, Begoña-
dc.contributor.authorGranado Lorencio, Fernando-
dc.contributor.authorMartín, Antonio-
dc.identifier.citationJournal of Nutrition 134(11): 3021-3025 (2004)es_ES
dc.description5 páginas, 1 figura, 2 tablas.-- Nutrición humana y Metabolismo.es_ES
dc.description.abstractCurrent evidence supports a significant association between fruit and vegetable intake and health. In this study, we assessed the effect of consuming a vegetable-soup "gazpacho" on vitamin C and biomarkers of oxidative stress and inflammation in a healthy human population. We also examined the association between vitamin C and F2-isoprostanes (8-epiPGF2α), uric acid (UA), prostaglandin E2 (PGE2), monocyte chemotactic protein-1 (MCP-1), and the cytokines, tumor necrosis factor-α (TNF-α), interleukin-1ß (IL-1ß), and IL-6. Gazpacho is a Mediterranean dish defined as a ready-to-use vegetable soup, containing ∼80% crude vegetables rich in vitamin C. Subjects (6 men, 6 women) enrolled in this study consumed 500 mL/d of gazpacho corresponding to an intake of 72 mg of vitamin C. On d 1, subjects consumed the gazpacho in one dose; from d 2 until the end of the study, d 14, 250 mL was consumed in the morning and 250 mL in the afternoon. Blood was collected before drinking the soup (baseline) and on d 7 and 14. Baseline plasma vitamin C concentrations did not differ between men and women (P = 0.060). Compared with baseline, the vitamin C concentration was significantly higher on d 7 and 14 of the intervention in both men and women (P < 0.05). Baseline plasma levels of UA and F2-isoprostanes were higher (P ≤ 0.002) in men than in women. The F2-isoprostanes decreased on d 14 in men and women (P ≤ 0.041), and UA decreased in men (P = 0.028). The concentrations of vitamin C and 8-epiPGF2α were inversely correlated (r = –0.585, P = 0.0002). Plasma PGE2 and MCP-1 concentrations decreased in men and women (P ≤ 0.05) on d 14, but those of TNF-α, IL-1ß, and IL-6 did not change. Consumption of the vegetable soup decreases oxidative stress and biomarkers of inflammation, which indicates that the protective effect of vegetables may extend beyond their antioxidant capacity.es_ES
dc.description.sponsorshipSupported in part by Coordinated Grant 07G/0040/2000–07G/0041/2000, and Grant 07G/0053/2003 (Comunidad Autónoma de Madrid); Grant AGL2002– 04059-C02–02 (Ministry of Science and Technology), Madrid, Spain (M.P.C.); and a Fulbright/Ministry of Education, Culture and Sports Award for Postdoctoral Research in the United States of America, Visiting Scholar Program, Commission for Cultural, Educational and Scientific Exchange between the United States of America and Spain, and a Ramón y Cajal Research Contract (Ministry of Science and Technology), Madrid, Spain (C.S.-M.).es_ES
dc.publisherAmerican Society for Nutritiones_ES
dc.subjectVegetable soupes_ES
dc.subjectVitamin Ces_ES
dc.titleConsumption of High-Pressurized Vegetable Soup Increases Plasma Vitamin C and Decreases Oxidative Stress and Inflammatory Biomarkers in Healthy Humanses_ES
dc.description.peerreviewedPeer reviewedes_ES
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