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High-Pressurized Orange Juice Consumption Affects Plasma Vitamin C, Antioxidative Status and Inflammatory Markers in Healthy Humans

AuthorsSánchez-Moreno, Concepción CSIC ORCID ; Cano, M. Pilar CSIC ORCID ; Ancos, Begoña de CSIC ORCID ; Plaza, Lucía CSIC ORCID; Olmedilla Alonso, Begoña CSIC ORCID ; Granado Lorencio, Fernando; Martín, Antonio CSIC ORCID
KeywordsHigh-pressurized orange juice
Vitamin C
C-reactive protein
Prostaglandin E2
Issue DateJul-2003
PublisherAmerican Society for Nutrition
CitationJournal of Nutrition 133(7): 2204-2209 (2003)
AbstractWe examined the bioavailability of vitamin C in orange juice processed using high pressure (HP) and its effects on plasma levels of vitamin C, uric acid (UA), F2-isoprostanes (8-epiPGF2α), C-reactive protein (CRP) and prostaglandin E2 (PGE2) in a healthy human population. Subjects (6 men, 6 women) enrolled in the study consumed 500 mL/d of HP orange juice for 14 d, corresponding to an intake of 250 mg of vitamin C. On d 1 of the study, subjects drank the juice in one dose; on d 2 until the end of the study, d 14, they drank 250 mL in the morning and 250 mL in the afternoon. Blood was collected every h for 6 h, on d 1, and then on d 7 and 14 of the study. Baseline plasma vitamin C concentration was higher (P = 0.014) in women (55.8 ± 3.8 µmol/L) than in men (42.8 ± 2.1 µmol/L). The maximum plasma vitamin C increase occurred 3 h after drinking the juice, and it remained elevated on d 7 and 14. Plasma 8-epiPGF2α concentration did not differ between men and women at baseline. However, it was lower at the end of the study in both men (P = 0.044) and women (P = 0.034). Plasma levels of vitamin C and 8-epiPGF2α were inversely correlated (r = -0.615, P = 0.001). Plasma CRP concentrations tended to be lower on d 14 than at baseline in men (P = 0.317) and women (P = 0.235). Plasma PGE2 was lower at the end of the study in both men and women (P ≤ 0.037). Drinking orange juice increases plasma vitamin C, and decreases 8-epiPGF2α and PGE2 levels in humans, which may help reduce the risk of chronic diseases.
Description6 páginas, 2 figuras, 2 tablas.
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