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dc.contributor.authorKargieman, Lucila-
dc.contributor.authorSantana, Noemí-
dc.contributor.authorMengod Los Arcos, Guadalupe-
dc.contributor.authorCelada, Pau-
dc.contributor.authorArtigas, Francesc-
dc.date.accessioned2011-04-13T08:55:13Z-
dc.date.available2011-04-13T08:55:13Z-
dc.date.issued2007-09-11-
dc.identifier.citationProceedings of the National Academy of Sciences of the USA 104(37): 14843-14848 (2007)es_ES
dc.identifier.issn0027-8424-
dc.identifier.urihttp://hdl.handle.net/10261/34573-
dc.description.abstractNMDA receptor (NMDA-R) antagonists are extensively used as schizophrenia models because of their ability to evoke positive and negative symptoms as well as cognitive deficits similar to those of the illness. Cognitive deficits in schizophrenia are associated with prefrontal cortex (PFC) abnormalities. These deficits are of particular interest because an early improvement in cognitive performance predicts a better long-term clinical outcome. Here, we examined the effect of the noncompetitive NMDA-R antagonist phencyclidine (PCP) on PFC function to understand the cellular and network elements involved in its schizomimetic actions. PCP induces a marked disruption of the activity of the PFC in the rat, increasing and decreasing the activity of 45% and 33% of the pyramidal neurons recorded, respectively (22% of the neurons were unaffected). Concurrently, PCP markedly reduced cortical synchrony in the delta frequency range (0.3–4 Hz) as assessed by recording local field potentials. The subsequent administration of the antipsychotic drugs haloperidol and clozapine reversed PCP effects on pyramidal cell firing and cortical synchronization. PCP increased c-fos expression in PFC pyramidal neurons, an effect prevented by the administration of clozapine. PCP also enhanced c-fos expression in the centromedial and mediodorsal (but not reticular) nuclei of the thalamus, suggesting the participation of enhanced thalamocortical excitatory inputs. These results shed light on the involvement of PFC in the schizomimetic action of NMDA-R antagonists and show that antipsychotic drugs may partly exert their therapeutic effect by normalizing a disrupted PFC activity, an effect that may add to subcortical dopamine receptor blockade.es_ES
dc.description.sponsorshipThis work was supported by Grant SAF 2004-05525 from the Ministry of Health. Support from Generalitat de Catalunya Grant 2005SGR00758 and Spanish Ministry of Health, Instituto de Salud Carlos III, RETICS Grant RD06/0011(REM-TAP Network) is also acknowledged. L.K. and N.S. are recipients of predoctoral fellowships from the Ministry of Science and Education.-
dc.language.isoenges_ES
dc.publisherNational Academy of Sciences (U.S.)es_ES
dc.rightsclosedAccesses_ES
dc.subjectNeuronal oscillationses_ES
dc.subjectNMDA receptor antagonistses_ES
dc.subjectSchizophreniaes_ES
dc.subjectDelta frequencyes_ES
dc.subjectThalamuses_ES
dc.titleAntipsychotic drugs reverse the disruption in prefrontal cortex function produced by NMDA receptor blockade with phencyclidinees_ES
dc.typeartículoes_ES
dc.identifier.doi10.1073/pnas.0704848104-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1073/pnas.0704848104es_ES
dc.identifier.e-issn1091-6490-
dc.identifier.pmid17785415-
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
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