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Title

Antipsychotic drugs reverse the disruption in prefrontal cortex function produced by NMDA receptor blockade with phencyclidine

AuthorsKargieman, Lucila CSIC ORCID; Santana, Noemí CSIC ORCID; Mengod Los Arcos, Guadalupe CSIC ORCID; Celada, Pau CSIC ORCID; Artigas, Francesc CSIC ORCID
KeywordsNeuronal oscillations
NMDA receptor antagonists
Schizophrenia
Delta frequency
Thalamus
Issue Date11-Sep-2007
PublisherNational Academy of Sciences (U.S.)
CitationProceedings of the National Academy of Sciences of the USA 104(37): 14843-14848 (2007)
AbstractNMDA receptor (NMDA-R) antagonists are extensively used as schizophrenia models because of their ability to evoke positive and negative symptoms as well as cognitive deficits similar to those of the illness. Cognitive deficits in schizophrenia are associated with prefrontal cortex (PFC) abnormalities. These deficits are of particular interest because an early improvement in cognitive performance predicts a better long-term clinical outcome. Here, we examined the effect of the noncompetitive NMDA-R antagonist phencyclidine (PCP) on PFC function to understand the cellular and network elements involved in its schizomimetic actions. PCP induces a marked disruption of the activity of the PFC in the rat, increasing and decreasing the activity of 45% and 33% of the pyramidal neurons recorded, respectively (22% of the neurons were unaffected). Concurrently, PCP markedly reduced cortical synchrony in the delta frequency range (0.3–4 Hz) as assessed by recording local field potentials. The subsequent administration of the antipsychotic drugs haloperidol and clozapine reversed PCP effects on pyramidal cell firing and cortical synchronization. PCP increased c-fos expression in PFC pyramidal neurons, an effect prevented by the administration of clozapine. PCP also enhanced c-fos expression in the centromedial and mediodorsal (but not reticular) nuclei of the thalamus, suggesting the participation of enhanced thalamocortical excitatory inputs. These results shed light on the involvement of PFC in the schizomimetic action of NMDA-R antagonists and show that antipsychotic drugs may partly exert their therapeutic effect by normalizing a disrupted PFC activity, an effect that may add to subcortical dopamine receptor blockade.
Publisher version (URL)http://dx.doi.org/10.1073/pnas.0704848104
URIhttp://hdl.handle.net/10261/34573
DOI10.1073/pnas.0704848104
ISSN0027-8424
E-ISSN1091-6490
Appears in Collections:(IIBB) Artículos




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