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http://hdl.handle.net/10261/34541
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Lladó-Pelfort, Laia | - |
dc.contributor.author | Artigas, Francesc | - |
dc.contributor.author | Celada, Pau | - |
dc.date.accessioned | 2011-04-12T12:37:06Z | - |
dc.date.available | 2011-04-12T12:37:06Z | - |
dc.date.issued | 2010-08 | - |
dc.identifier.citation | British Journal of Pharmacology 160(8): 1929-1940 (2010) | es_ES |
dc.identifier.issn | 0007-1188 | - |
dc.identifier.uri | http://hdl.handle.net/10261/34541 | - |
dc.description.abstract | [Background and purpose]: F15599, a novel 5-hydroxytryptamine (5-HT)1A receptor agonist with 1000-fold selectivity for 5-HT compared with other monoamine receptors, shows antidepressant and procognitive activity at very low doses in animal models. We examined the in vivo activity of F15599 at somatodendritic autoreceptors and postsynaptic 5-HT1A heteroreceptors. | es_ES |
dc.description.abstract | [Experimental approach]: In vivo single unit and local field potential recordings and microdialysis in the rat. | es_ES |
dc.description.abstract | [Key results]: F15599 increased the discharge rate of pyramidal neurones in medial prefrontal cortex (mPFC) from 0.2 µg·kg−1 i.v and reduced that of dorsal raphe 5-hydroxytryptaminergic neurones at doses >10-fold higher (minimal effective dose 8.2 µg·kg−1 i.v.). Both effects were reversed by the 5-HT1A antagonist (±)WAY100635. F15599 did not alter low frequency oscillations (∼1 Hz) in mPFC. In microdialysis studies, F15599 increased dopamine output in mPFC (an effect dependent on the activation of postsynaptic 5-HT1A receptors) with an ED50 of 30 µg·kg−1 i.p., whereas it reduced hippocampal 5-HT release (an effect dependent exclusively on 5-HT1A autoreceptor activation) with an ED50 of 240 µg·kg−1 i.p. Likewise, application of F15599 by reverse dialysis in mPFC increased dopamine output in a concentration-dependent manner. All neurochemical responses to F15599 were prevented by administration of (±)WAY100635. | es_ES |
dc.description.abstract | [Conclusions and implications]: These results indicate that systemic administration of F15599 preferentially activates postsynaptic 5-HT1A receptors in PFC rather than somatodendritic 5-HT1A autoreceptors. This regional selectivity distinguishes F15599 from previously developed 5-HT1A receptor agonists, which preferentially activate somatodendritic 5-HT1A autoreceptors, suggesting that F15599 may be particularly useful in the treatment of depression and of cognitive deficits in schizophrenia. | es_ES |
dc.description.sponsorship | Work supported by grants SAF 2007-62378, FIS PI060264 and Pierre Fabre Médicament. L.L.-P. is supported by a JAE fellowship from CSIC. P.C. is supported by the Researcher Stabilization Program of the Health Department of the Generalitat de Catalunya. | - |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley-Blackwell | es_ES |
dc.rights | closedAccess | es_ES |
dc.subject | 5-HT1A receptors | es_ES |
dc.subject | Dopamine | es_ES |
dc.subject | Pyramidal neurones | es_ES |
dc.subject | Depression | es_ES |
dc.subject | Prefrontal cortex | es_ES |
dc.subject | Schizophrenia | es_ES |
dc.subject | Microdialysis | es_ES |
dc.subject | Local field potential | es_ES |
dc.title | Preferential in vivo action of F15599, a novel 5-HT1A receptor agonist, at postsynaptic 5-HT1A receptors | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1111/j.1476-5381.2010.00738.x | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1111/j.1476-5381.2010.00738.x | es_ES |
dc.identifier.e-issn | 1476-5381 | - |
dc.identifier.pmid | 20649591 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
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