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dc.contributor.authorSantana, Noemí-
dc.contributor.authorTroyano-Rodriguez, Eva-
dc.contributor.authorMengod Los Arcos, Guadalupe-
dc.contributor.authorCelada, Pau-
dc.contributor.authorArtigas, Francesc-
dc.date.accessioned2011-04-12T11:15:26Z-
dc.date.available2011-04-12T11:15:26Z-
dc.date.issued2011-01-18-
dc.identifier.citationBiological Psychiatry 69(10): 918-927 (2011)es_ES
dc.identifier.issn0006-3223-
dc.identifier.urihttp://hdl.handle.net/10261/34529-
dc.description.abstract[Background]: Noncompetitive N-methyl-D-aspartate receptor antagonists are widely used as pharmacological models of schizophrenia. Their neurobiological actions are still poorly understood, although the prefrontal cortex (PFC) appears as a key target area.es_ES
dc.description.abstract[Methods]: We examined the effect of phencyclidine (PCP) on neuronal activity of the mediodorsal (MD) and centromedial (CM) thalamic nuclei, reciprocally connected with the PFC, using extracellular recordings (n = 50 neurons from 35 Wistar rats) and c-fos expression.es_ES
dc.description.abstract[Results]: Phencyclidine (.25 mg/kg intravenous [IV]) markedly disorganized the activity of MD/CM neurons, increasing (424%) and decreasing (41%) the activity of 57% and 20% of the recorded neurons, respectively (23% remained unaffected). Phencyclidine reduced delta oscillations (.15–4 Hz) as assessed by recording local field potentials. The subsequent clozapine administration (1 mg/kg IV) reversed PCP effects on neuronal discharge and delta oscillations. Double in situ hybridization experiments revealed that PCP (10 mg/kg intraperitoneal [IP]) markedly increased c-fos expression in glutamatergic neurons of several cortical areas (prefrontal, somatosensory, retrosplenial, entorhinal) and in thalamic nuclei, including MD/CM. Phencyclidine also increased c-fos expression in the amygdala; yet, it had a small effect in the hippocampus. Phencyclidine did not increase c-fos expression in gamma-aminobutyric acidergic cells except in hippocampus, amygdala, somatosensory, and retrosplenial cortices. Clozapine (5 mg/kg IP) had no effect by itself but significantly prevented PCP-induced c-fos expression.es_ES
dc.description.abstract[Conclusions]: Phencyclidine likely exerts its psychotomimetic action by increasing excitatory neurotransmission in thalamo-cortico-thalamic networks involving, among others, PFC, retrosplenial, and somatosensory cortices. The antipsychotic action of clozapine includes, among other actions, an attenuation of the neuronal hyperactivity in thalamocortical networks.es_ES
dc.description.sponsorshipThe work leading to these results has received funding from the Innovative Medicines Initiative Joint Undertaking under Grant Agreement N° 115008 (NEWMEDS). The Innovative Medicines Initiative Joint Undertaking is a public-private partnership between the European Union and the European Federation of Pharmaceutical Industries and Associations. Support from Grants SAF 2007-62378 and FIS PI09/1245 is also acknowledged. PC is supported by the Researcher Stabilization Program of the Health Department of the Generalitat de Catalunya. NS is supported by Centro de Investigación Biomédica en Red de Salud Mental. ET is the recipient of a predoctoral fellowship from the Ministerio de Ciencia e Innovación de España.-
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsclosedAccesses_ES
dc.subjectAntipsychoticses_ES
dc.subjectDelta oscillationses_ES
dc.subjectGABAergic interneuronses_ES
dc.subjectGlutamatees_ES
dc.subjectPrefrontal cortexes_ES
dc.subjectPyramidal neuronses_ES
dc.subjectThalamuses_ES
dc.titleActivation of thalamocortical networks by the N-methyl-D-aspartate receptor antagonist phencyclidine: reversal by clozapinees_ES
dc.typeartículoes_ES
dc.identifier.doi10.1016/j.biopsych.2010.10.030-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/doi:10.1016/j.biopsych.2010.10.030es_ES
dc.identifier.e-issn1873-2402-
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
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