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Closed Access item Bioactive diterpenes from Orthosiphon labiatus and Salvia africana-lutea

Authors:Hussein, Ahmed A.
Meyer, Jacobus J. M
Jimeno, M. Luisa
Rodríguez, Benjamín
Issue Date:2007
Publisher:American Chemical Society
American Society of Pharmacognosy
Citation:Journal of Natural Products 70 : 293-295 (2007)
Abstract:The known (+)-trans-ozic acid (1) and two new labdane diterpenoids (2 and 3) have been isolated from an ethanol extract of Orthosiphon labiatus. The structures of 2 and 3 were established mainly by 1D and 2D NMR spectroscopic means. The ethanolic extract of SalVia africana-lutea afforded the known abietane diterpenoids carnosol (4), rosmadial (5), and carnosic acid (characterized as its derivative 6). Compounds 3 and 6 exhibited MICs of 157 and 28 íM, respectively, against Mycobacterium tuberculosis, while 2 and 6 showed cytotoxic activity with IC50 82 and 69 íM, respectively, against a breast (MCF-7) human cancer cell line.
Publisher version (URL):http://dx.doi.org/10.1021/np0680376
Appears in Collections:(CENQUIOR) Artículos

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