Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/3400
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | The functional modulation of epigenetic regulators by alternative splicing |
Autor: | Lois, Sergi CSIC; Blanco-García, Noemí CSIC; Martínez-Balbás, Marian CSIC ORCID ; Cruz, Xavier de la CSIC ORCID | Fecha de publicación: | 25-jul-2007 | Editor: | BioMed Central | Citación: | BMC Genomics. 2007; 8: 252 | Resumen: | [Background] Epigenetic regulators (histone acetyltransferases, methyltransferases, chromatinremodelling
enzymes, etc) play a fundamental role in the control of gene expression by modifying
the local state of chromatin. However, due to their recent discovery, little is yet known about their
own regulation. This paper addresses this point, focusing on alternative splicing regulation, a
mechanism already known to play an important role in other protein families, e.g. transcription
factors, membrane receptors, etc. [Results] To this end, we compiled the data available on the presence/absence of alternative splicing for a set of 160 different epigenetic regulators, taking advantage of the relatively large amount of unexplored data on alternative splicing available in public databases. We found that 49 % (70 % in human) of these genes express more than one transcript. We then studied their alternative splicing patterns, focusing on those changes affecting the enzyme's domain composition. In general, we found that these sequence changes correspond to different mechanisms, either repressing the enzyme's function (e.g. by creating dominant-negative inhibitors of the functional isoform) or creating isoforms with new functions. [Conclusion] We conclude that alternative splicing of epigenetic regulators can be an important tool for the function modulation of these enzymes. Considering that the latter control the transcriptional state of large sets of genes, we propose that epigenetic regulation of gene expression is itself strongly regulated by alternative splicing. |
Descripción: | This article is available from: http://www.biomedcentral.com/1471-2164/8/252 | Versión del editor: | http://dx.doi.org/10.1186/1471-2164-8-252 | URI: | http://hdl.handle.net/10261/3400 | DOI: | 10.1186/1471-2164-8-252 | ISSN: | 1471-2164 |
Aparece en las colecciones: | (IBMB) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
picrender.pdf | Principal | 713,72 kB | Adobe PDF | Visualizar/Abrir |
1471-2164-8-252-S1.xls | Archivo adicional 1 | 154,5 kB | Microsoft Excel | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
9
checked on 05-abr-2024
SCOPUSTM
Citations
14
checked on 15-abr-2024
WEB OF SCIENCETM
Citations
13
checked on 29-feb-2024
Page view(s)
437
checked on 19-abr-2024
Download(s)
360
checked on 19-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.