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Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/33944
Title: New Gly-Pro-Glu (GPE) analogues: Expedite solid-phase synthesis and biological activity
Authors: Alonso De Diego, Sergio A.; Gutiérrez-Rodríguez, Marta; Pérez de Vega, M. Jesús; Casabona, Diego; Cativiela, Carlos; González-Muñiz, Rosario; Herranz, Rosario; Cenarruzabeitia, Edurne; Frechilla, Diana; Río, Joaquín del; Jimeno, M. Luisa; García-López, M. Teresa
Keywords: GPE analogues
Solid-phase synthesis
Neuroprotective activity
Issue Date: 2006
Publisher: Elsevier
Citation: Bioorganic & Medicinal Chemistry Letters 16 : 1392–1396 (2006)
Abstract: A suitable solid-phase approach, based on Fmoc/tBu methodology and on the use of 2-chlorotrityl resin, allowed a rapid and efficient preparation of new GPE analogues. Most of the synthesized tripeptides displayed glutamate receptor binding affinity comparable to that of GPE, but only a few derivatives showed significant neuroprotective activity.
Publisher version (URL): http://dx.doi.org/10.1016/j.bmcl.2005.11.040
URI: http://hdl.handle.net/10261/33944
DOI: doi:10.1016/j.bmcl.2005.11.040
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