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Título : New Gly-Pro-Glu (GPE) analogues: Expedite solid-phase synthesis and biological activity
Autor : Alonso De Diego, Sergio A., Gutiérrez-Rodríguez, Marta, Pérez de Vega, M. Jesús, Casabona, Diego, Cativiela, Carlos, González-Muñiz, Rosario, Herranz, Rosario, Cenarruzabeitia, Edurne, Frechilla, Diana, Del Río, Joaquín, Jimeno, M. Luisa, García-López, M. Teresa
Palabras clave : GPE analogues
Solid-phase synthesis
Neuroprotective activity
Fecha de publicación : 2006
Editor: Elsevier
Resumen: A suitable solid-phase approach, based on Fmoc/tBu methodology and on the use of 2-chlorotrityl resin, allowed a rapid and efficient preparation of new GPE analogues. Most of the synthesized tripeptides displayed glutamate receptor binding affinity comparable to that of GPE, but only a few derivatives showed significant neuroprotective activity.
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DOI: doi:10.1016/j.bmcl.2005.11.040
Citación : Bioorganic & Medicinal Chemistry Letters 16 : 1392–1396 (2006)
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