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Closed Access item New Gly-Pro-Glu (GPE) analogues: Expedite solid-phase synthesis and biological activity

Authors:Alonso De Diego, Sergio A.
Gutiérrez-Rodríguez, Marta
Pérez de Vega, M. Jesús
Casabona, Diego
Cativiela, Carlos
González-Muñiz, Rosario
Herranz, Rosario
Cenarruzabeitia, Edurne
Frechilla, Diana
Del Río, Joaquín
Jimeno, M. Luisa
García-López, M. Teresa
Keywords:GPE analogues, Solid-phase synthesis, Neuroprotective activity
Issue Date:2006
Citation:Bioorganic & Medicinal Chemistry Letters 16 : 1392–1396 (2006)
Abstract:A suitable solid-phase approach, based on Fmoc/tBu methodology and on the use of 2-chlorotrityl resin, allowed a rapid and efficient preparation of new GPE analogues. Most of the synthesized tripeptides displayed glutamate receptor binding affinity comparable to that of GPE, but only a few derivatives showed significant neuroprotective activity.
Publisher version (URL):http://dx.doi.org/10.1016/j.bmcl.2005.11.040
Appears in Collections:(CENQUIOR) Artículos

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