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Título: | Analogues of the neuroprotective tripeptide Gly-Pro-Glu (GPE): synthesis and structure–activity relationships |
Autor: | Alonso De Diego, Sergio A. CSIC; Muñoz, Pilar; González-Muñiz, Rosario CSIC ORCID; Cenarruzabeitia, Edurne CSIC; Frechilla, Diana; Río, Joaquín del CSIC; Jimeno, M. Luisa CSIC ORCID; García-López, M. Teresa CSIC | Palabras clave: | Gly-Pro-Glu (GPE) Neuroprotection Structure–activity relationships |
Fecha de publicación: | 3-mar-2005 | Editor: | Elsevier | Citación: | Bioorganic & Medicinal Chemistry Letters 15 : 2279–2283 (2005) | Resumen: | A series of GPE analogues, including modifications at the Pro and/or Glu residues, was prepared and evaluated for their NMDA binding and neuroprotective effects. Main results suggest that the pyrrolidine ring puckering of the Pro residue plays a key role in the biological responses, while the preference for cis or trans rotamers around the Gly-Pro peptide bond is not important. | Versión del editor: | http://dx.doi.org/10.1016/j.bmcl.2005.03.015 | URI: | http://hdl.handle.net/10261/33717 | DOI: | 10.1016/j.bmcl.2005.03.015 | E-ISSN: | 0960-894X |
Aparece en las colecciones: | (CENQUIOR) Artículos (IQM) Artículos |
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