English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/33717
Title: Analogues of the neuroprotective tripeptide Gly-Pro-Glu (GPE): synthesis and structure–activity relationships
Authors: Alonso De Diego, Sergio A.; Muñoz, Pilar; González-Muñiz, Rosario; Cenarruzabeitia, Edurne; Frechilla, Diana; Del Río, Joaquín; Jimeno, M. Luisa; García-López, M. Teresa
Keywords: Gly-Pro-Glu (GPE)
Structure–activity relationships
Issue Date: 3-Mar-2005
Publisher: Elsevier
Citation: Bioorganic & Medicinal Chemistry Letters 15 : 2279–2283 (2005)
Abstract: A series of GPE analogues, including modifications at the Pro and/or Glu residues, was prepared and evaluated for their NMDA binding and neuroprotective effects. Main results suggest that the pyrrolidine ring puckering of the Pro residue plays a key role in the biological responses, while the preference for cis or trans rotamers around the Gly-Pro peptide bond is not important.
Publisher version (URL): http://dx.doi.org/10.1016/j.bmcl.2005.03.015
URI: http://hdl.handle.net/10261/33717
DOI: doi:10.1016/j.bmcl.2005.03.015
E-ISSN: 0960-894X
Appears in Collections:(CENQUIOR) Artículos
Files in This Item:
There are no files associated with this item.
Show full item record

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.