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Closed Access item Analogues of the neuroprotective tripeptide Gly-Pro-Glu (GPE): synthesis and structure–activity relationships

Authors:Alonso De Diego, Sergio A.
Muñoz, Pilar
González-Muñiz, Rosario
Cenarruzabeitia, Edurne
Frechilla, Diana
Del Río, Joaquín
Jimeno, M. Luisa
García-López, M. Teresa
Keywords:Gly-Pro-Glu (GPE), Neuroprotection, Structure–activity relationships
Issue Date:3-Mar-2005
Citation:Bioorganic & Medicinal Chemistry Letters 15 : 2279–2283 (2005)
Abstract:A series of GPE analogues, including modifications at the Pro and/or Glu residues, was prepared and evaluated for their NMDA binding and neuroprotective effects. Main results suggest that the pyrrolidine ring puckering of the Pro residue plays a key role in the biological responses, while the preference for cis or trans rotamers around the Gly-Pro peptide bond is not important.
Publisher version (URL):http://dx.doi.org/10.1016/j.bmcl.2005.03.015
E-ISSNmetadata.dc.identifier.doi = DOI:0960-894X
Appears in Collections:(CENQUIOR) Artículos

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