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Título : Analogues of the neuroprotective tripeptide Gly-Pro-Glu (GPE): synthesis and structure–activity relationships
Autor : Alonso De Diego, Sergio A., Muñoz, Pilar, González-Muñiz, Rosario, Cenarruzabeitia, Edurne, Frechilla, Diana, Del Río, Joaquín, Jimeno, M. Luisa, García-López, M. Teresa
Palabras clave : Gly-Pro-Glu (GPE)
Structure–activity relationships
Fecha de publicación : 3-Mar-2005
Editor: Elsevier
Resumen: A series of GPE analogues, including modifications at the Pro and/or Glu residues, was prepared and evaluated for their NMDA binding and neuroprotective effects. Main results suggest that the pyrrolidine ring puckering of the Pro residue plays a key role in the biological responses, while the preference for cis or trans rotamers around the Gly-Pro peptide bond is not important.
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DOI: doi:10.1016/j.bmcl.2005.03.015
Citación : Bioorganic & Medicinal Chemistry Letters 15 : 2279–2283 (2005)
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