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Closed Access item The neuroprotective activity of GPE tripeptide analogues does not correlate with glutamate receptor binding affinity

Authors:Alonso De Diego, Sergio A.
Gutiérrez-Rodríguez, Marta
Pérez de Vega, M. Jesús
González-Muñiz, Rosario
Herranz, Rosario
Martín-Martínez, Mercedes
Cenarruzabeitia, Edurne
Frechilla, Diana
Del Río, Joaquín
Jimeno, M. Luisa
García-López, M. Teresa
Keywords:Neuroprotection, Glutamate receptors binding, Tripeptides, Peptidomimetics, GPE
Issue Date:1-Jul-2006
Publisher:Elsevier
Citation:Bioorganic & Medicinal Chemistry Letters 16(13): 3396-3400 (2006)
Abstract:The influence of several modifications on the GPE tripeptide structure upon the binding to GluRs and on their neuroprotective effects has been studied. The results indicated that the prevention of neuronal death showed by GPE and some analogues is not directly related to their affinity at glutamate receptors.
Publisher version (URL):http://dx.doi.org/10.1016/j.bmcl.2006.04.033
URI:http://hdl.handle.net/10261/33631
ISSN:0960-894X
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Appears in Collections:(IQM) Artículos

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