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Title: Biological consequences of oxygen desaturation and respiratory effort in an acute animal model of obstructive sleep apnea (OSA)
Authors: Nácher, María, Farré, Ramon, Montserrat, Josep M., Torres, Marta, Navajas, Daniel, Bulbena, Oriol, Serrano-Mollar, Anna
Keywords: Obstructive apnea
Inflammation
Endothelial dysfunction
Respiratory effort
Hypoxia
Animal model
Issue Date: 8-Sep-2009
Publisher: Elsevier
Abstract: [Background]: An animal model mimicking all the factors involved in obstructive sleep apnea (OSA) is useful for investigating mechanisms because the associated comorbidity usually present in such patients is an important limitation.
[Aim]: To test the hypothesis that hypoxia/normoxia and respiratory effort have different effects on the induction of inflammatory response and endothelial dysfunction in an acute rat model of OSA.
[Methods]: Four groups of anesthetized rats were studied (n = 8): (1) sham; (2) apnea: obstructions (15 s each, 60/h, for 3 h); (3) apnea + O2: obstructions and breathing oxygen-enriched air to avoid hypoxia and (4) intermittent hypoxia/normoxia. Inflammatory and endothelial mediators were measured as outcomes along with NF-κB in the lung and diaphragm.
[Results]: TNF-α and IL-1β significantly increased in all groups compared with sham. NF-κB in the lung was increased in apnea and hypoxia/normoxia groups, but not in apnea + O2 group. In diaphragm tissue, NF-κB was only significant in apnea compared to sham. Significant differences were found in the ratio thromboxane-B2/6-keto-Prostaglandin-F1α between apnea and hypoxia/normoxia compared to sham but not in apnea + O2.
[Conclusions]: Oxygen desaturations and respiratory efforts play a role in the induction of systemic inflammation but only hypoxia/normoxia induces endothelial dysfunction. These data suggest a potential role for oxygen therapy in patients with OSA.
Description: El pdf del artículo es el manuscrito de autor.
Publisher version (URL): http://dx.doi.org/10.1016/j.sleep.2008.09.014
URI: http://hdl.handle.net/10261/33423
ISSN: 1389-9457
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Citation: Sleep Medicine 10(8): 892-897 (2009)
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