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Title

Single and repeated bleomycin intratracheal instillations lead to different biomechanical changes in lung tissue

AuthorsPinart, Mariona; Serrano-Mollar, Anna CSIC ORCID; Llatjós, R.; Rocco, P. R. M.; Romero, Pablo V.
KeywordsBleomycin
Acute alveolitis
Myeloperoxydase
Interstitial lung diseases
Lung mechanics
Issue Date31-Mar-2009
PublisherElsevier
CitationRespiratory Physiology and Neurobiology 166(1): 41-46 (2009)
AbstractSingle dose of bleomycin induces acute alveolitis followed by a reparative process whilst a repeated dose results in progressive fibrosis, which may lead to distinct lung tissue biomechanical changes. To test this hypothesis, rats were intratracheally instilled with saline (N = 11) or bleomycin (2.5 U/kg) once (SD, N = 8) or three times (RD, N = 9) one week apart, and sacrificed 28 days after challenge. Forced oscillatory mechanics as well as the amount of collagen fibre and myeloperoxidase content (MPOL) were studied in lung tissue strips. Both elastic modulus (H), tissue damping (G), and MPOL increased only in RD-challenged rats. Although fibroblast focus was found in RD, collagen fibre content increased in both challenged groups. However, the amount of collagen fibre in SD group was not enough to induce lung tissue mechanical changes. In conclusion, repeated doses of bleomycin induce inflammatory and fibrogenic behaviour with biomechanical changes mimicking interstitial lung disease in humans.
DescriptionEl pdf del artículo es la versión post-print.
Publisher version (URL)http://dx.doi.org/10.1016/j.resp.2009.01.002
URIhttp://hdl.handle.net/10261/33413
DOI10.1016/j.resp.2009.01.002
ISSN1569-9048
E-ISSN1878-1519
Appears in Collections:(IIBB) Artículos




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