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Modulation of the hydrophilic character and influence on the biocompatibility of polyurethane-siloxane based hybrids

AuthorsJiménez-Gallegos, R.; Téllez-Jurado, L.; Rodríguez-Lorenzo, Luis M.
KeywordsSol-gel process
Biomedical applications
Issue Date2011
PublisherSociedad Española de Cerámica y Vidrio
CitationBol. Soc. Esp. Ceram. Vidr. Vol 50. 1, 1-8, enero-febrero 2011
AbstractOrganic-inorganic hybrid materials are known for their outstanding chemical and physical properties. Although some studies have been published regarding the use of hybrids for biomedical applications, relationship between hydrophilic character and biodegradation, bioactivity and biocompatibility has not been studied yet. The sol–gel method has been chosen for the manufacturing of siloxane-polyurethane hybrids for the exceptional potential of the method to obtain nanostructured materials. The effect of the amount of the urethane oligomer (OPU) on the structure, hydrophilic character, degradability, bioactivity and citotoxicity was investigated. Gelling time of these hybrids increases linearly with the decrease on the Siloxane/OPU ratio up to an 80/20 value. Hydrophilic character of the hybrids can be modulated and affects dramatically the degradation rate of the specimens. A hybrid with a 50/50 Siloxane/OPU ratio displayed an appropriate degradation rate, bioactivity and lack of cell toxicity that makes this material a candidate for further studies for applications in bone regeneration.
Publisher version (URL)http://dx.doi.org/10.3989/cyv.012011
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