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http://hdl.handle.net/10261/33151
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Adell, Albert | - |
dc.contributor.author | Artigas, Francesc | - |
dc.date.accessioned | 2011-03-08T10:12:55Z | - |
dc.date.available | 2011-03-08T10:12:55Z | - |
dc.date.issued | 1998-11 | - |
dc.identifier.citation | British Journal of Pharmacology 125 (6) : 1361–1367 (1998) | es_ES |
dc.identifier.issn | 0007-1188 | - |
dc.identifier.uri | http://hdl.handle.net/10261/33151 | - |
dc.description.abstract | The present study has examined several characteristics of the release of 5-HT in the median raphe nucleus in terms of its dependence of nerve impulse, provenance of a vesicular storage fraction as well as the regulatory role played by 5-HT1A receptors. Tetrodotoxin (1 microM) and reserpine (5 mg kg(-1), i.p.) virtually suppressed the output of 5-HT. The administration of EEDQ (10 mg kg(-1), i.p.) did not alter the basal release of 5-HT but abolished the reduction of 5-HT release induced by 8-OH-DPAT (0.1 mg kg(-1), s.c.). The perfusion of 1-100 microM of 8-OH-DPAT or the novel 5-HT1A agonist BAY x 3702 decreased the efflux of 5-HT, whereas the perfusion of the 5-HT1A antagonist WAY-100635 failed to alter 5-HT release. The decrease in dialysate 5-HT induced by 100 microM 8-OH-DPAT was reversed by the concurrent perfusion of 100 microM WAY-100635. Also, the perfusion of 100 microM WAY-100635 for 2 h inhibited partly the reduction of 5-HT release evoked by the systemic administration of 8-OH-DPAT (0.1 mg kg(-1)). These results indicate that extracellular 5-HT in the median raphe nucleus is stored in vesicles and released in an impulse-dependent manner. Also, the basal release of 5-HT in the median raphe nucleus does not appear to be under the tonic control of somatodendritic 5-HT1A receptors by endogenous 5-HT. Instead, this feedback mechanism seems to be triggered when an excess of the transmitter or a 5-HT1A agonist is present in the extracellular space of the median raphe nucleus. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | John Wiley & Sons | es_ES |
dc.rights | closedAccess | es_ES |
dc.subject | 5-hydroxytryptamine | es_ES |
dc.subject | 5-HT1A receptors | es_ES |
dc.subject | reserpine | es_ES |
dc.subject | TTX | es_ES |
dc.subject | EEDQ | es_ES |
dc.subject | 8-OH-DPAT | es_ES |
dc.subject | BAY×3702 | es_ES |
dc.subject | WAY-100635 | es_ES |
dc.subject | median raphe nucleus | es_ES |
dc.subject | microdialysis | es_ES |
dc.title | A microdialysis study of the in vivo release of serotonin in the median raphe nucleus of the rat | es_ES |
dc.title.alternative | A microdialysis study of the in vivo release of 5-HT in the median raphe nucleus of the rat | - |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1038/sj.bjp.0702206 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | http://onlinelibrary.wiley.com/doi/10.1038/sj.bjp.0702206/full | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1038/sj.bjp.0702206 | - |
dc.identifier.e-issn | 1476-5381 | - |
dc.identifier.pmid | 9863668 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.cerifentitytype | Publications | - |
item.openairetype | artículo | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
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