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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Bortolozzi, Analía | - |
dc.contributor.author | Amargós-Bosch, Mercè | - |
dc.contributor.author | Toth, Miklos | - |
dc.contributor.author | Artigas, Francesc | - |
dc.contributor.author | Adell, Albert | - |
dc.date.accessioned | 2011-03-04T08:43:52Z | - |
dc.date.available | 2011-03-04T08:43:52Z | - |
dc.date.issued | 2004-03 | - |
dc.identifier.citation | Journal of Neurochemistry 88 (6) :1373-1379 (2004) | es_ES |
dc.identifier.issn | 0022-3042 | - |
dc.identifier.uri | http://hdl.handle.net/10261/33047 | - |
dc.description.abstract | In the dorsal raphe nucleus (DR), extracellular serotonin (5-HT) regulates serotonergic transmission through 5-HT1A autoreceptors. In this work we used in vivo microdialysis to examine the effects of stressful and pharmacological challenges on DR 5-HT efflux in 5-HT1A receptor knockout (5-HT1A-/-) mice and their wild-type counterparts (5-HT1A+/+). Baseline 5-HT concentrations did not differ between both lines of mice, which is consistent with a lack of tonic control of 5-HT1A autoreceptors on DR 5-HT release. (R)-(+)-8-Hydroxy-2-(di-n-propylamino)tetralin hydrobromide (8-OH-DPAT, 0.5 mg/kg) reduced 5-HT levels to 30% of basal values in 5-HT1A+/+ mice, but not in 5-HT1A-/- mice. The selective 5-HT1B receptor agonist 1,4-dihydro-3-(1,2,3,6-tetrahydro-4-pyridinyl)-5H-pyrrolo[3,2-b]pyridin-5-one dihydrochloride (CP 93129, 300 micro m) reduced dialysate 5-HT to the same extent (30-40% of baseline) in the two genotypes, which suggests a lack of compensatory changes in 5-HT1B receptors in the DR of such mutant mice. Both a saline injection and handling for 3 min increased DR dialysate 5-HT in mutants, but not in 5-HT1A+/+ mice. Fluoxetine (5 and 20 mg/kg) elevated 5-HT in a dose-dependent manner in both genotypes. However, this effect was markedly more pronounced in the 5-HT1A-/- mice. The increased responsiveness of the extracellular 5-HT in the DR of 5-HT1A receptor knockout mice reflects a lack of the autoinhibitory control exerted by 5-HT1A autoreceptors. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley-Blackwell | es_ES |
dc.rights | openAccess | es_ES |
dc.subject | dorsal raphe nucleus | es_ES |
dc.subject | fluoxetine | es_ES |
dc.subject | 5-HT1A receptor knockout mice | es_ES |
dc.subject | 5-HT1B receptors | es_ES |
dc.subject | microdialysis | es_ES |
dc.subject | Stress | es_ES |
dc.title | In vivo efflux of serotonin in the dorsal raphe nucleus of 5-HT1A receptor knockout mice | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1046/j.1471-4159.2003.02267.x | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | http://onlinelibrary.wiley.com/doi/10.1046/j.1471-4159.2003.02267.x/pdf | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1046/j.1471-4159.2003.02267.x | - |
dc.identifier.e-issn | 1471-4159 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
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j.1471-4159.2003.02267.x.pdf | 241,45 kB | Adobe PDF | Visualizar/Abrir |
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