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|Title:||Association between CCK-AR gene and schizophrenia with auditory hallucinations|
|Authors:||Toirac, Ivette; Sanjuán, Julio; Aguilar, Eduardo J.; González, José Carlos; Artigas, Francesc ; Rivero, Olga; Nájera, Carmen; Moltó, María D.; Frutos, Rosa de|
|Publisher:||Lippincott Williams & Wilkins|
|Citation:||Psychiatric Genetics 17(2): 47-53 (2007)|
|Abstract:||[Objective]: Previous studies on a possible association between CCK-AR polymorphisms and schizophrenia have been controversial. The aim of the present study was to assess a potential association between schizophrenic patients with auditory hallucinations and polymorphisms of the CCK-AR gene.|
[Methods]: A set of single nucleotide polymorphisms mainly located in the regulatory region of the CCK-AR gene was analysed in a sample of 163 Diagnostic and statistical manual of mental disorders-IV-diagnosed schizophrenic patients and 162 healthy controls
[Results]: Significant differences in the genotype (P=0.011) and allele (P=0.0009) frequencies of the +121C/G SNP (located in the 5' regulatory region) were found between patients and controls. The excess of the C allele in the patient group remained significant after Bonferroni correction (P=0.03). However, functional in vitro assays, did not reveal significant differences on gene expression between +121G and +121C alleles of this SNP. Further investigations revealed two risk haplotypes: +121C/+978A/+984T (P=0.01) and +121C/+978T/+984C (P=0.0091) as well as a protective haplotype: +121G/+978T/+984T (P=0.0001).
[Conclusion]: Our data support a possible role of the CCK-AR gene in the vulnerability to schizophrenia in patients with auditory hallucinations, and suggest remarkable allele heterogeneity.
|Publisher version (URL):||http://dx.doi.org/10.1097/YPG.0b013e3280298292|
|Appears in Collections:||(IIBB) Artículos|