English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/32661
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Environmentally sensitive paramagnetic and diamagnetic contrast agents for nuclear magnetic resonance imaging and spectroscopy

AuthorsPacheco-Torres, Jesús; Calle, Daniel ; Lizarbe, Blanca ; Negri, Viviana ; Ubide, Carmen; Fayos, Rosa ; López-Larrubia, Pilar ; Ballesteros, Paloma ; Cerdán, Sebastián
KeywordsSaturation-transfer cest
MRI contrast
Fluorinated 2-nitroimidazole
Diffusion-tensor
Tumor hypoxia
Acetamide sr-4554
Issue DateJan-2011
PublisherBentham Science Publishers
CitationCurrent Topics in Medicinal Chemistry 11(1): 115-130 (2011)
AbstractEven though alterations in the microenvironmental properties of tissues underlie the development of the most prevalent and morbid pathologies, they are not directly observable in vivo by Magnetic Resonance Imaging (MRI) or Spectroscopy (MRS) methods. This circumstance has lead to the development of a wide variety of exogenous paramagnetic and diamagnetic MRI and MRS probes able to inform non invasively on microenvironmental variables such as pH, pO(2), ion concentration o even temperature. This review covers the fundamentals of environmental contrast and the current arsenal of endogenous and exogenous MRI and MRS contrast enhancing agents available to visualize it. We begin describing the physicochemical background necessary to understand paramagnetic and diamagnetic contrast enhancement with a special reference to novel magnetization transfer and C-13 hiperpolarization strategies. We describe then the main macrocyclic structures used to support the environmentally sensitive paramagnetic sensors, including CEST and PARACEST pH sensitive probes, temperature probes and enzyme activity or gene expression activatable probes. Finally we address the most commonly used diamagnetic contrast agents including imidazolic derivatives to reveal extracellular pH and tissue pO(2) values by MRS. The potential applications of these agents in mutimodal and molecular imaging approaches are discussed.
Publisher version (URL)http://dx.doi.org/10.2174/156802611793611904
URIhttp://hdl.handle.net/10261/32661
DOI10.2174/156802611793611904
ISSN1568-0266
Appears in Collections:(IIBM) Artículos
Files in This Item:
File Description SizeFormat 
Current topics in medicinal chemistry 2011 vol11 n1 pp115.pdf2,3 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.