Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/32643
Title: Kainate receptors: Perspectives from the past decade
Authors: Lerma Gómez, Juan, Rodríguez-Moreno, Antonio, Guinea, D., Paternain, Ana V.
Issue Date: 2001
Publisher: IOS Press
Series/Report no.: Biomedical and Health Research
45
Abstract: The potent excitatory amino acid glutamate mediates its excitatory effects through a wide variety of specific ionotropic receptors, including NMDA, AMPA and kainate receptors. During the past decade, a whole family of subunits for kainate receptor has been identified, isolated and cloned. Although this receptor has been rather elusive to experimentation, its function is becoming established in some sytems. Recent results support the idea that of kainate receptors participate in synaptic transmission and that their activation downregulates GABAergic inhibition by modulating the reliability of GABA synapses. It has also been established taht in addition to their ionotropic activity, kainate receptor activation may trigger a second messenger cascade that results in the inhibition of GABA release. Thus, kainate receptors have a dual signaling mechanism. Given their strategic locatio, kainate receptors may play an important role in the etiology of epilepsy and could represent a future target for antiepileptics drigs.
Description: 10 páginas, 5 figuras.-- Edited by: L. Turski, D.D. Schoepp and E.A. Cavalheiro.
Publisher version (URL): http://www.iospress.nl/fs_nw/books.html
URI: http://hdl.handle.net/10261/32643
ISBN: 978-1-58603-072-8
Citation: Excitatory amino acids: Ten years later: 139-148 (2001)
Appears in Collections:(IC) Libros y partes de libros

Files in This Item:
There are no files associated with this item.
Show full item record
 
CSIC SFX LinksSFX Query

Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.