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Closed Access item Kainate receptor physiology

Authors:Lerma Gómez, Juan
Issue Date:Feb-2006
Publisher:Elsevier
Citation:Current Opinion in Pharmacology 6(1): 89-97 (2006)
Abstract:Glutamate receptors constitute a complex signalling system at most of the excitatory synapses in the brain. Of the known ionotropic glutamate receptors, kainate receptors are ubiquitous in the central nervous system, and a considerable amount of data indicates that this class of receptors is present at both sides of the synapse. Pre- and postsynaptic kainate receptors are able to regulate both transmission of information and excitability in a synapse-specific manner. Proteins interacting with kainate receptor subunits are being identified and functional studies have provided evidence of the existence of a dual signalling system. It has become clear that these receptors have a role in synaptic plasticity and that they might also have a fundamental role in epilepsy through the strategic control of network excitability. However, the role of kainate receptors in other brain pathologies remains obscure.
Description:9 páginas, 2 figuras.
Publisher version (URL):http://dx.doi.org/10.1016/j.coph.2005.08.004
URI:http://hdl.handle.net/10261/32590
ISSN:1471-4892
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Appears in Collections:(IN) Artículos

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