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|Title:||Noncanonical Signaling by Ionotropic Kainate Receptors|
|Authors:||Rozas, José Luis; Paternain, Ana V.; Lerma Gómez, Juan|
|Citation:||Neuron 39(3): 543-553 (2003)|
|Abstract:||The potent neurotoxin kainate activates ion channel-forming receptors. However, it can also activate a G protein-coupled signaling pathway to inhibit transmitter release in central neurons. It remains unclear whether the same receptor complex is involved in both signaling activities. Here we show that in a population of dorsal root ganglion cells, exposure to kainate elicits a G protein-dependent increase in intracellular Ca2+. Furthermore, in these cells a brief exposure to kainate inhibited the K+-induced Ca2+ increase, a process that was sensitive to the G protein inhibitor Pertussis toxin and inhibitors of protein kinase C. This metabotropic action did not require ion channel activity and was not observed in neurons prepared from mice deficient for the ion channel-forming subunit GluR5. These results indicate that GluR5, an ion channel-forming subunit, signals through a second messenger cascade, inhibiting voltage-dependent Ca2+ channels. Thus, such a system represents a noncanonical signaling route of ion channel-forming receptors.|
|Description:||11 páginas, 8 figuras.|
|Publisher version (URL):||http://dx.doi.org/10.1016/S0896-6273(03)00436-7|
|Appears in Collections:||(IC) Artículos|
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