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Two populations of kainate receptors with separate signaling mechanisms in hippocampal interneurons

AuthorsRodríguez-Moreno, Antonio; López-García, Juan C.; Lerma Gómez, Juan
Issue DateFeb-2000
PublisherNational Academy of Sciences (U.S.)
CitationProceedings of the National Academy of Sciences of the United States of America 97(3): 1293-1298 (2000)
AbstractConsistent with the epileptogenic and deleterious effects of the potent neurotoxin kainate, the activation of kainate receptors reduces the synaptic inhibition induced by the amino acid γ-aminobutyric acid (GABA). Extrapolating from these data led to the conclusion that kainate receptors are located presynaptically. However, kainate directly depolarizes the inhibitory interneurons, causing them to fire repeatedly. This effect might indirectly decrease the size of inhibitory postsynaptic currents recorded from pyramidal cells and places in doubt the presynaptic location for kainate receptors. Here we show that both effects, membrane depolarization and the reduction of inhibitory potentials, can be dissociated by several means, particularly by the natural agonist of kainate receptors, glutamate. Indeed, when applied at low concentrations, glutamate inhibited GABA release without affecting the firing rate of GABA interneurons. These results indicate that CA1 interneurons contain two populations of kainate receptors, each with different agonist sensitivity and coupled to distinct signaling pathways.
Description6 páginas, 4 figuras.
Publisher version (URL)http://www.pnas.org/content/97/3/1293.abstract
Appears in Collections:(IC) Artículos
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