Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/32562
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Rodríguez-Moreno, Antonio | - |
dc.contributor.author | Sistiaga, Alessandra | - |
dc.contributor.author | Lerma Gómez, Juan | - |
dc.contributor.author | Sánchez-Prieto, José | - |
dc.date.accessioned | 2011-02-18T10:11:07Z | - |
dc.date.available | 2011-02-18T10:11:07Z | - |
dc.date.issued | 1998-12 | - |
dc.identifier.citation | Neuron 21(6): 1477-1486 (1998) | es_ES |
dc.identifier.issn | 0896-6273 | - |
dc.identifier.uri | http://hdl.handle.net/10261/32562 | - |
dc.description | 10 páginas, 8 figuras. | es_ES |
dc.description.abstract | We have explored whether the desensitization of metabotropic glutamate receptors (mGluRs) coupled to phosphoinositide hydrolysis affects the role that they play in modulating glutamate release. In hippocampal nerve terminals, the agonist 3,5-dihydroxyphenylglycine (DHPG) facilitated evoked glutamate release, but a second stimulation 5 min later reduced rather than facilitated release. After a 30 min interval between stimulations, DHPG again facilitated glutamate release. In hippocampal slices, DHPG caused an inhibition of excitatory postsynaptic currents (EPSCs) recorded from CA1 neurons. However, when the effects of ambient glutamate were prevented, mGluR activation initially induced a facilitation of synaptic transmission, followed by an inhibition. We conclude that group I mGluRs have a dual action on glutamate release, switching from facilitatory to inhibitory upon receptor desensitization triggered by low concentrations of glutamate. | es_ES |
dc.description.sponsorship | This work was supported by grants from the Dirección General de Investigación Científica y Técnica (PM-0008/96 to J. L. and PB97/0321 to J. S.-P.) and from the European Union (BMH-CT96–0228 to J. S.-P.). A. R.-M. and A. S. were supported by Formación Personal Investigador fellowships from the Ministerio de Educación y Cultura (Spain). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | closedAccess | es_ES |
dc.title | Switch from Facilitation to Inhibition of Excitatory Synaptic Transmission by Group I mGluR Desensitization | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1016/S0896-6273(00)80665-0 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1016/S0896-6273(00)80665-0 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | artículo | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
Aparece en las colecciones: | (IC) Artículos |
CORE Recommender
SCOPUSTM
Citations
117
checked on 18-abr-2024
WEB OF SCIENCETM
Citations
111
checked on 24-feb-2024
Page view(s)
332
checked on 23-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.