Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/32562
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Switch from Facilitation to Inhibition of Excitatory Synaptic Transmission by Group I mGluR Desensitization |
Autor: | Rodríguez-Moreno, Antonio CSIC ORCID; Sistiaga, Alessandra; Lerma Gómez, Juan CSIC ORCID; Sánchez-Prieto, José | Fecha de publicación: | dic-1998 | Editor: | Elsevier | Citación: | Neuron 21(6): 1477-1486 (1998) | Resumen: | We have explored whether the desensitization of metabotropic glutamate receptors (mGluRs) coupled to phosphoinositide hydrolysis affects the role that they play in modulating glutamate release. In hippocampal nerve terminals, the agonist 3,5-dihydroxyphenylglycine (DHPG) facilitated evoked glutamate release, but a second stimulation 5 min later reduced rather than facilitated release. After a 30 min interval between stimulations, DHPG again facilitated glutamate release. In hippocampal slices, DHPG caused an inhibition of excitatory postsynaptic currents (EPSCs) recorded from CA1 neurons. However, when the effects of ambient glutamate were prevented, mGluR activation initially induced a facilitation of synaptic transmission, followed by an inhibition. We conclude that group I mGluRs have a dual action on glutamate release, switching from facilitatory to inhibitory upon receptor desensitization triggered by low concentrations of glutamate. | Descripción: | 10 páginas, 8 figuras. | Versión del editor: | http://dx.doi.org/10.1016/S0896-6273(00)80665-0 | URI: | http://hdl.handle.net/10261/32562 | DOI: | 10.1016/S0896-6273(00)80665-0 | ISSN: | 0896-6273 |
Aparece en las colecciones: | (IC) Artículos |
Mostrar el registro completo
CORE Recommender
SCOPUSTM
Citations
117
checked on 10-abr-2024
WEB OF SCIENCETM
Citations
111
checked on 24-feb-2024
Page view(s)
332
checked on 18-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.