Please use this identifier to cite or link to this item:
|Title:||Kainate Receptor Modulation of GABA Release Involves a Metabotropic Function|
|Authors:||Rodríguez-Moreno, Antonio; Lerma Gómez, Juan|
|Citation:||Neuron 20(6): 1211-1218 (1998)|
|Abstract:||The mechanism through which kainate receptors downregulate the release of GABA in the hippocampus is not known. We have found that the action of kainate on the hippocampal inhibitory postsynaptic current (IPSC) is mediated by a metabotropic process that is sensitive to Pertussis toxin (PTx) and independent of ion channel current. The downregulation of GABA IPSCs by kainate was also prevented in a dose-dependent manner by calphostin C, a specific inhibitor of PKC, and the inhibition of phospholipase C (PLC) drastically reduced the action of kainate. The effect of kainate was completely occluded by phorbol esters and by increasing extracellular Ca2+ but remained unaltered after inhibition or activation of protein kinase A (PKA). These results demonstrate that the activation of kainate receptors triggers a second messenger cascade, which results in the stimulation of PKC, and therefore document a metabotropic action of kainate receptors, which results in the inhibition of GABA release.|
|Description:||8 páginas, 7 figuras.|
|Publisher version (URL):||http://dx.doi.org/10.1016/S0896-6273(00)80501-2|
|Appears in Collections:||(IC) Artículos|
Files in This Item:
There are no files associated with this item.
Show full item record
WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.