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Título: | Kainate Receptors Presynaptically Downregulate GABAergic Inhibition in the Rat Hippocampus |
Autor: | Rodríguez-Moreno, Antonio CSIC ORCID; Herreras, Óscar CSIC ORCID ; Lerma Gómez, Juan CSIC ORCID | Fecha de publicación: | oct-1997 | Editor: | Elsevier | Citación: | Neuron 19(4): 893-901 (1997) | Resumen: | Using microcultured neurons and hippocampal slices, we found that under conditions that completely block AMPA receptors, kainate induces a reduction in the effectiveness of GABAergic synaptic inhibition. Evoked inhibitory postsynaptic currents (IPSCs) were decreased by kainate by up to 90%, showing a bell-shaped dose-response curve similar to that of native kainate-selective receptors. The down-regulation of GABAergic inhibition was not affected by antagonism of metabotropic receptors, while it was attenuated by CNQX. Kainate increased synaptic failures and reduced the frequency of miniature IPSCs, indicating a presynaptic locus of action. In vivo experiments using brain dialysis demonstrated that kainate reversibly abolished recurrent inhibition and induced an epileptic-like electroencephalogram (EEG) activity. These results indicate that kainate receptor activation downregulates GABAergic inhibition by modulating the reliability of GABA synapses. | Descripción: | 9 páginas, 5 figuras. | Versión del editor: | http://dx.doi.org/10.1016/S0896-6273(00)80970-8 | URI: | http://hdl.handle.net/10261/32553 | DOI: | 10.1016/S0896-6273(00)80970-8 | ISSN: | 0896-6273 |
Aparece en las colecciones: | (IC) Artículos |
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