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Title: Kainate Receptors Presynaptically Downregulate GABAergic Inhibition in the Rat Hippocampus
Authors: Rodríguez-Moreno, Antonio, Herreras, Óscar, Lerma Gómez, Juan
Issue Date: Oct-1997
Publisher: Elsevier
Abstract: Using microcultured neurons and hippocampal slices, we found that under conditions that completely block AMPA receptors, kainate induces a reduction in the effectiveness of GABAergic synaptic inhibition. Evoked inhibitory postsynaptic currents (IPSCs) were decreased by kainate by up to 90%, showing a bell-shaped dose-response curve similar to that of native kainate-selective receptors. The down-regulation of GABAergic inhibition was not affected by antagonism of metabotropic receptors, while it was attenuated by CNQX. Kainate increased synaptic failures and reduced the frequency of miniature IPSCs, indicating a presynaptic locus of action. In vivo experiments using brain dialysis demonstrated that kainate reversibly abolished recurrent inhibition and induced an epileptic-like electroencephalogram (EEG) activity. These results indicate that kainate receptor activation downregulates GABAergic inhibition by modulating the reliability of GABA synapses.
Description: 9 páginas, 5 figuras.
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ISSN: 0896-6273
???metadata.dc.identifier.doi???: 10.1016/S0896-6273(00)80970-8
Citation: Neuron 19(4): 893-901 (1997)
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