Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/32423
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Deletion of H-Ras decreases renal fibrosis and myofibroblast activation following ureteral obstruction in mice |
Autor: | Grande, M. Teresa CSIC ORCID; Fuentes-Calvo, Isabel; Arévalo, Miguel; Heredia, Fabiana; Santos de Dios, Eugenio CSIC ORCID CVN ; Martínez-Salgado, Carlos; Rodríguez-Puyol, Diego; Nieto, M. Ángela CSIC ORCID ; López-Novoa, José M. | Palabras clave: | Cell biology and structure Extracellular matrix Fibroblasts Interstitial fibrosis Obstructive nephropathy |
Fecha de publicación: | 2-mar-2010 | Editor: | Nature Publishing Group | Citación: | Kidney International 77(6): 509-518 (2010) | Resumen: | Tubulointerstitial fibrosis is characterized by the presence of myofibroblasts that contribute to extracellular matrix accumulation. These cells may originate from resident fibroblasts, bone-marrow-derived cells, or renal epithelial cells converting to a mesenchymal phenotype. Ras GTPases are activated during renal fibrosis and play crucial roles in regulating both cell proliferation and TGF-β-induced epithelial–mesenchymal transition. Here we set out to assess the contribution of Ras to experimental renal fibrosis using the well-established model of unilateral ureteral obstruction. Fifteen days after obstruction, both fibroblast proliferation and inducers of epithelial–mesenchymal transition were lower in obstructed kidneys of H-ras knockout mice and in fibroblast cell lines derived from these mice. Interestingly, fibronectin, collagen I accumulation, overall interstitial fibrosis, and the myofibroblast population were also lower in the knockout than in the wild-type mice. As expected, we found lower levels of activated Akt in the kidneys and cultured fibroblasts of the knockout. Whether Ras inhibition will turn out to prevent progression of renal fibrosis will require more direct studies. | Descripción: | 10 páginas. | Versión del editor: | http://dx.doi.org/10.1038/ki.2009.498 | URI: | http://hdl.handle.net/10261/32423 | DOI: | 10.1038/ki.2009.498 | ISSN: | 0085-2538 |
Aparece en las colecciones: | (IN) Artículos (IBMCC) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Deletion of H-Ras decreases renal fibrosis and myofibroblas.pdf | Articulo | 169,81 kB | Adobe PDF | Visualizar/Abrir |
Figures.pdf | Figuras | 948,21 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
53
checked on 14-mar-2024
WEB OF SCIENCETM
Citations
54
checked on 25-feb-2024
Page view(s)
466
checked on 19-mar-2024
Download(s)
355
checked on 19-mar-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.