Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/32413
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Título : Inflammation and EMT: an alliance towards organ fibrosis and cancer progression
Autor : López-Novoa, José M., Nieto, M. Ángela
Palabras clave : Inflammation
Epithelial–mesenchymal transition
TGF-β
TNF-alfa
NF-κB
Fecha de publicación : 2009
Editor: Wiley-Blackwell
Resumen: Recent advances in our understanding of the molecular pathways that govern the association of inflammation with organ fibrosis and cancer point to the epithelial to mesenchymal transition (EMT) as the common link in the progression of these devastating diseases. The EMT is a crucial process in the development of different tissues in the embryo and its reactivation in the adult may be regarded as a physiological attempt to control inflammatory responses and to ‘heal’ damaged tissue. However, in pathological contexts such as in tumours or during the development of organ fibrosis, this healing response adopts a sinister nature, steering these diseases towards metastasis and organ failure. Importantly, the chronic inflammatory microenvironment common to fibrotic and cancer cells emerges as a decisive factor in the induction of the pathological EMT.
Descripción : 12 páginas, 3 figuras, 1 cuadro.
Versión del editor: http://dx.doi.org/10.1002/emmm.200900043
URI : http://hdl.handle.net/10261/32413
ISSN: 1757-4676
DOI: 10.1002/emmm.200900043
Citación : EMBO molecular medicine 1(6-7): 303-314 (2009)
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