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Closed Access item Non-coding RNAs take centre stage in epithelial-to-mesenchymal transition

Authors:Cano, Amparo
Nieto, M. Ángela
Issue Date:Aug-2008
Publisher:Elsevier
Citation:Trends in Cell Biology 18(8): 357-359 (2008)
Abstract:Noncoding RNAs are emerging as central players in gene expression regulation through the targeting of a plethora of mRNAs. Several recent papers report on the regulation of the epithelial phenotype by the miR-200 (200 family of miRNAs) family and a natural antisense transcript, both acting on the E-cadherin repressors zinc-finger E-box-binding homeobox factors ZEB1 and ZEB2. These findings open new avenues for understanding the modulation of the epithelial-to-mesenchymal transition in physiological and pathological situations.
Description:3 páginas, 1 figura.
Publisher version (URL):http://dx.doi.org/10.1016/j.tcb.2008.05.005
URI:http://hdl.handle.net/10261/32406
ISSN:0962-8924
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