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Título

Reactivation of Snail Genes in Renal Fibrosis and Carcinomas: A Process of Reversed Embryogenesis?

AutorBoutet, Agnès; Esteban, Miguel A.; Maxwell, Patrick H.; Nieto, M. Ángela
Palabras claveSnail
Renal fibrosis
Renal cell carcinoma
Epithelial-mesenchymal transitions
Tumor progression
Epithelial homeostasis
Fecha de publicación15-mar-2007
EditorLandes Bioscience
CitaciónCell Cycle 6(6): 638-642 (2007)
ResumenWhile the activity oepithelialf Snail genes is required during embryonic development for the formation of different tissues and organs, they must be repressed in the adult in order to maintain epithelial integrity and homeostasis. Indeed, pathological activation of Snail in epithelial tumors induces malignancy and the recurrence of tumors. Here we show that in dedifferentiated areas of human renal carcinomas, Snail undergoes a process of reactivation. In addition to tumor progression, renal fibrosis is also linked to the activity of Snail genes and indeed, reactivation of Snail in the adult kidney is sufficient to induce fibrosis. Thus, Snail genes illustrate a paradigm whereby reactivation of crucial embryonic genes in adult tissues provokes the onset of devastating diseases.
Descripción5 páginas, 4 figuras.
Versión del editorhttp://dx.doi.org/10.4161/cc.6.6.4022
URIhttp://hdl.handle.net/10261/32374
DOI10.4161/cc.6.6.4022
ISSN1538-4101
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