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Open Access item Reactivation of Snail Genes in Renal Fibrosis and Carcinomas: A Process of Reversed Embryogenesis?

Authors:Boutet, Agnès
Esteban, Miguel A.
Maxwell, Patrick H.
Nieto, M. Ángela
Keywords:Snail, Renal fibrosis, Renal cell carcinoma, Epithelial-mesenchymal transitions, Tumor progression, Epithelial homeostasis
Issue Date:15-Mar-2007
Publisher:Landes Bioscience
Citation:Cell Cycle 6(6): 638-642 (2007)
Abstract:While the activity oepithelialf Snail genes is required during embryonic development for the formation of different tissues and organs, they must be repressed in the adult in order to maintain epithelial integrity and homeostasis. Indeed, pathological activation of Snail in epithelial tumors induces malignancy and the recurrence of tumors. Here we show that in dedifferentiated areas of human renal carcinomas, Snail undergoes a process of reactivation. In addition to tumor progression, renal fibrosis is also linked to the activity of Snail genes and indeed, reactivation of Snail in the adult kidney is sufficient to induce fibrosis. Thus, Snail genes illustrate a paradigm whereby reactivation of crucial embryonic genes in adult tissues provokes the onset of devastating diseases.
Description:5 páginas, 4 figuras.
Publisher version (URL):http://dx.doi.org/10.4161/cc.6.6.4022
Appears in Collections:(IN) Artículos

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