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dc.contributor.authorBoutet, Agnès-
dc.contributor.authorFrutos, Cristina A. de-
dc.contributor.authorMaxwell, Patrick H.-
dc.contributor.authorMayol, M. José-
dc.contributor.authorRomero, J.-
dc.contributor.authorNieto, M. Ángela-
dc.date.accessioned2011-02-15T13:18:06Z-
dc.date.available2011-02-15T13:18:06Z-
dc.date.issued2006-11-
dc.identifier.citationEmbo Journal 25(23): 5603-5613 (2006)es_ES
dc.identifier.issn0261-4189-
dc.identifier.urihttp://hdl.handle.net/10261/32371-
dc.description11 páginas, 7 figuras.es_ES
dc.description.abstractDuring embryonic development, the kidney epithelium originates from cells that undergo a mesenchymal to epithelial transition (MET). The reverse process, epithelium to mesenchyme transition (EMT), has been implicated in epithelial tumor progression and in the fibrosis that leads to end-stage kidney failure. Snail transcription factors induce both natural and pathological EMT, but their implication in renal development and disease is still unclear. We show that Snail genes are downregulated during the MET that occurs during renal development and that this is correlated with Cadherin-16 expression. Snail suppresses Cadherin-16 via the direct repression of the kidney differentiation factor HNF-1beta, a novel route by which Snail disrupts epithelial homeostasis. Indeed, Snail activation is sufficient to induce EMT and kidney fibrosis in adult transgenic mice. Significantly, Snail is also activated in patients with renal fibrosis. Thus, Snail expression is suppressed during renal development and it must remain silent in the mature kidney where its aberrant activation leads to fibrosis.es_ES
dc.description.sponsorshipThis work has been supported by the Spanish Ministry of Education and Science (BFU2004-02665, BFU2005-05772 and NAN2004-09230-C04-04) to MAN. CAF was also supported by BFU2004-02665 and NAN2004-09230-C04-04. AB was supported by a Marie Curie Fellowship and by the Spanish Ministry of Education and Science.es_ES
dc.language.isoenges_ES
dc.publisherNature Publishing Groupes_ES
dc.rightsclosedAccesses_ES
dc.subjectCadherin-16es_ES
dc.subjectEpithelial–mesenchymal transitiones_ES
dc.subjectHNF-1betaes_ES
dc.subjectRenal fibrosises_ES
dc.subjectSnail transcription factorses_ES
dc.titleSnail activation disrupts tissue homeostasis and induces fibrosis in the adult kidneyes_ES
dc.typeartículoes_ES
dc.identifier.doi10.1038/sj.emboj.7601421-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1038/sj.emboj.7601421es_ES
dc.identifier.pmid17093497-
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
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