Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/32371
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Título : Snail activation disrupts tissue homeostasis and induces fibrosis in the adult kidney
Autor : Boutet, Agnès, Frutos, Cristina A. de, Maxwell, Patrick H., Mayol, M. José, Romero, J., Nieto, M. Ángela
Palabras clave : Cadherin-16
Epithelial–mesenchymal transition
HNF-1beta
Renal fibrosis
Snail transcription factors
Fecha de publicación : Nov-2006
Editor: Nature Publishing Group
Resumen: During embryonic development, the kidney epithelium originates from cells that undergo a mesenchymal to epithelial transition (MET). The reverse process, epithelium to mesenchyme transition (EMT), has been implicated in epithelial tumor progression and in the fibrosis that leads to end-stage kidney failure. Snail transcription factors induce both natural and pathological EMT, but their implication in renal development and disease is still unclear. We show that Snail genes are downregulated during the MET that occurs during renal development and that this is correlated with Cadherin-16 expression. Snail suppresses Cadherin-16 via the direct repression of the kidney differentiation factor HNF-1beta, a novel route by which Snail disrupts epithelial homeostasis. Indeed, Snail activation is sufficient to induce EMT and kidney fibrosis in adult transgenic mice. Significantly, Snail is also activated in patients with renal fibrosis. Thus, Snail expression is suppressed during renal development and it must remain silent in the mature kidney where its aberrant activation leads to fibrosis.
Descripción : 11 páginas, 7 figuras.
Versión del editor: http://dx.doi.org/10.1038/sj.emboj.7601421
URI : http://hdl.handle.net/10261/32371
ISSN: 0261-4189
DOI: 10.1038/sj.emboj.7601421
Citación : Embo Journal 25(23): 5603-5613 (2006)
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