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Open Access item How to become neural crest: From segregation to delamination

Authors:Morales, Aixa V.
Barbas, Julio A.
Nieto, M. Ángela
Keywords:Neural crest cells, Epithelial-mesenchymal transition (EMT), Cell cycle, Cell survival, Transcription factors
Issue Date:Dec-2005
Publisher:Elsevier
Citation:Seminars in Cell and Developmental Biology 16(6): 655-662 (2005)
Abstract:The development of the neural crest up to the stage where they leave the neural tube can be observed as a series of concatenated but independent events that involve dorsalization of the neural plate/neural tube, neural crest induction, segregation and stabilization, epithelial to mesenchymal transition and delamination. During all these processes, the nascent neural crest cells are subjected to the influence of different signals and have to overcome competition for cell fate and apoptotic signals. In addition, striking rostrocaudal differences unveil how the regulatory cascades are somehow different but still can lead to the production of bona fide neural crest cells.
Description:8 páginas, 1 figura.
Publisher version (URL):http://dx.doi.org/10.1016/j.semcdb.2005.06.003
URI:http://hdl.handle.net/10261/32358
ISSN:1084-9521
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