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dc.contributor.authorManzanares, Miguel-
dc.contributor.authorBlanco Fernández de Valderrama, María José-
dc.contributor.authorNieto, M. Ángela-
dc.date.accessioned2011-02-15T09:23:09Z-
dc.date.available2011-02-15T09:23:09Z-
dc.date.issued2004-
dc.identifier.citationDevelopment Genes and Evolution 214(1): 47-53 (2004)es_ES
dc.identifier.issn0949-944X-
dc.identifier.urihttp://hdl.handle.net/10261/32353-
dc.description7 páginas, 3 figuras, 1 tabla.es_ES
dc.description.abstractSnail genes comprise a family of zinc-finger transcription factor coding genes with multiple roles in early embryonic development of metazoans. The evolutionary history of this family has been studied in detail, revealing an initial duplication in Snail and Scratch genes preceding the protostome/deuterostome split, and posterior independent duplication events in the lineages leading to insects and vertebrates. The distribution of mammalian and teleost Snail genes fits with current models for whole genome duplication events at the base of the vertebrate lineage, plus an extra duplication in teleosts. However, two very divergent Snail genes, one from mammals and the other from teleost fishes, fit poorly into the phylogenetic analysis of the family. By means of database mining and synteny analysis, we provide evidence for these genes being orthologues, and evidence that they originated in an early duplication at the base of the vertebrates resulting in three and not two Snail genes. We further show that all three Snail genes lie in regions of extensive paralogy, revealing their common origin through segmental or chromosomal duplication.es_ES
dc.description.sponsorshipThis work was supported by grants from the Spanish Ministry of Science and Technology to M.M. (BMC0203558) and to M.A.N. (BMC0200383). M.J.B. is a researcher of the Ramón y Cajal Program of the Spanish Ministry of Science and Technology.es_ES
dc.language.isoenges_ES
dc.publisherSpringeres_ES
dc.rightsclosedAccesses_ES
dc.subjectSnailes_ES
dc.subjectSmuces_ES
dc.subjectZNF313es_ES
dc.subjectGene duplicationes_ES
dc.subjectSyntenyes_ES
dc.titleSnail3 orthologues in vertebrates: divergent members of the Snail zinc-finger gene familyes_ES
dc.typeartículoes_ES
dc.identifier.doi10.1007/s00427-003-0373-1-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1007/s00427-003-0373-1es_ES
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