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Open Access item Treatment of disorders caused by changes in neurone axonal development

Other Titles:Tratamiento de enfermedades causadas por alteraciones del desarrollo axonal de neuronas
Authors:Marín Parra, Oscar
Rico Gonzalo, Beatriz
López-Bendito, Guillermina
Flames, Nuria
Lorenzo Vidal, Sonia
Sánchez Alcañiz, Juan Antonio
Keywords:Neuregulin 1, NRG1, Epidermal growth factor, Axonal development, Neurones
Issue Date:11-Oct-2007
Citation:International Publication Number: WO 2007/113361 A1
Abstract:[English] The invention relates to the use of a peptide that comprises the amino acid sequence of the epidermal growth factor-like domain (EGF domain) of neuregulin 1 (NRG1), or a functionally equivalent variant or fragment thereof, or of a polynucleotide that codes for said peptide or functionally equivalent fragment or variant, or of a compound that induces the production and/or activity of said NRG1, in the preparation of a pharmaceutical composition for treating disorders caused by changes in the axonal development of neurones in the nervous system.
[Español] La invención se relaciona, en general, con el tratamiento de enfermedades causadas por alteraciones del desarrollo axonal de las neuronas del sistema nervioso, particularmente en humanos, basado en el empleo de la neuregulina 1 (NRG1), o una variante o fragmento funcionalmente equivalente de la misma, o de un polinucleótido que codifica dicha proteína, variante o fragmento funcionalmente equivalente, o de un compuesto que potencia la producción y/o actividad de dicha NRG1.
Description:Filing Date: 2007-04-03.-- Priority Data: ES P200600882 (2006-04-05).
Appears in Collections:(IN) Patentes

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