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Título : Snail blocks the cell cycle and confers resistance to cell death
Autor : Vega, Sonia; Morales, Aixa V. ; Ocaña, Óscar H.; Nieto, M. Ángela
Palabras clave : Snail
Cell cycle
Cell death
Malignization
Chick embryo
Mouse embryo
Fecha de publicación : 2004
Editor: Cold Spring Harbor Laboratory. Press
Citación : Genes and Development 18(10): 1131-1143 (2004)
Resumen: The Snail zinc-finger transcription factors trigger epithelial-mesenchymal transitions (EMTs), endowing epithelial cells with migratory and invasive properties during both embryonic development and tumor progression. During EMT, Snail provokes the loss of epithelial markers, as well as changes in cell shape and the expression of mesenchymal markers. Here, we show that in addition to inducing dramatic phenotypic alterations, Snail attenuates the cell cycle and confers resistance to cell death induced by the withdrawal of survival factors and by pro-apoptotic signals. Hence, Snail favors changes in cell shape versus cell division, indicating that with respect to oncogenesis, although a deregulation/increase in proliferation is crucial for tumor formation and growth, this may not be so for tumor malignization. Finally, the resistance to cell death conferred by Snail provides a selective advantage to embryonic cells to migrate and colonize distant territories, and to malignant cells to separate from the primary tumor, invade, and form metastasis.
Descripción : 14 páginas, 9 figuras.-- et al.
Versión del editor: http://dx.doi.org/10.1101/gad.294104
URI : http://hdl.handle.net/10261/32348
DOI: 10.1101/gad.294104
ISSN: 0890-9369
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