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Title: Snail blocks the cell cycle and confers resistance to cell death
Authors: Vega, Sonia, Morales, Aixa V., Ocaña, Oscar H., Nieto, M. Ángela
Keywords: Snail
Cell cycle
Cell death
Chick embryo
Mouse embryo
Issue Date: 2004
Publisher: Cold Spring Harbor Laboratory. Press
Abstract: The Snail zinc-finger transcription factors trigger epithelial-mesenchymal transitions (EMTs), endowing epithelial cells with migratory and invasive properties during both embryonic development and tumor progression. During EMT, Snail provokes the loss of epithelial markers, as well as changes in cell shape and the expression of mesenchymal markers. Here, we show that in addition to inducing dramatic phenotypic alterations, Snail attenuates the cell cycle and confers resistance to cell death induced by the withdrawal of survival factors and by pro-apoptotic signals. Hence, Snail favors changes in cell shape versus cell division, indicating that with respect to oncogenesis, although a deregulation/increase in proliferation is crucial for tumor formation and growth, this may not be so for tumor malignization. Finally, the resistance to cell death conferred by Snail provides a selective advantage to embryonic cells to migrate and colonize distant territories, and to malignant cells to separate from the primary tumor, invade, and form metastasis.
Description: 14 páginas, 9 figuras.-- et al.
Publisher version (URL):
ISSN: 0890-9369
???metadata.dc.identifier.doi???: 10.1101/gad.294104
Citation: Genes and Development 18(10): 1131-1143 (2004)
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