English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/32348
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Snail blocks the cell cycle and confers resistance to cell death

AuthorsVega, Sonia; Morales, Aixa V. ; Ocaña, Oscar H.; Nieto, M. Ángela
KeywordsSnail
Cell cycle
Cell death
Malignization
Chick embryo
Mouse embryo
Issue Date2004
PublisherCold Spring Harbor Laboratory Press
CitationGenes and Development 18(10): 1131-1143 (2004)
AbstractThe Snail zinc-finger transcription factors trigger epithelial-mesenchymal transitions (EMTs), endowing epithelial cells with migratory and invasive properties during both embryonic development and tumor progression. During EMT, Snail provokes the loss of epithelial markers, as well as changes in cell shape and the expression of mesenchymal markers. Here, we show that in addition to inducing dramatic phenotypic alterations, Snail attenuates the cell cycle and confers resistance to cell death induced by the withdrawal of survival factors and by pro-apoptotic signals. Hence, Snail favors changes in cell shape versus cell division, indicating that with respect to oncogenesis, although a deregulation/increase in proliferation is crucial for tumor formation and growth, this may not be so for tumor malignization. Finally, the resistance to cell death conferred by Snail provides a selective advantage to embryonic cells to migrate and colonize distant territories, and to malignant cells to separate from the primary tumor, invade, and form metastasis.
Description14 páginas, 9 figuras.-- et al.
Publisher version (URL)http://dx.doi.org/10.1101/gad.294104
URIhttp://hdl.handle.net/10261/32348
DOI10.1101/gad.294104
ISSN0890-9369
Appears in Collections:(IC) Artículos
Files in This Item:
File Description SizeFormat 
snail_blocks_Vega.pdf425,99 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.