Please use this identifier to cite or link to this item:
|Title:||Biological Potential of a Functional Human SNAILRetrogene|
|Authors:||Locascio, Annamaria; Vega, Sonia; Frutos, Cristina A. de; Manzanares, Miguel; Nieto, M. Ángela|
|Publisher:||American Society for Biochemistry and Molecular Biology|
|Citation:||Journal of Biological Chemistry 277(41): 38803-38809 (2002)|
|Abstract:||Snail genes encode zinc finger transcription factors required for the development of vertebrate and invertebrate embryos. They trigger epithelial to mesenchymal transitions (EMTs), thereby allowing epithelial cells to emigrate from their place of origin and form tissues such as the mesoderm and the neural crest. Snail genes are also involved in the EMTs responsible for the acquisition of invasiveness during tumor progression. This aspect of their activity is associated with their ability to directly repress E-cadherin transcription. Here we describe the existence of an active human Snailretrogene, inserted within an intron of a novel evolutionarily conserved gene and expressed in different human tissues and cell lines. Functional analyses in cell culture show that this retrogene maintains the potential to induce EMTs, conferring migratory and invasive properties to epithelial cells. In light of this data, we have renamed it SNAIL-like, a new player that must be considered in both physiological and pathological studies of SNAIL function in humans.|
|Description:||7 páginas, 7 figuras.|
|Publisher version (URL):||http://www.jbc.org/content/277/41/38803.abstract|
|Appears in Collections:||(IC) Artículos|
Files in This Item:
There are no files associated with this item.
Show full item record
WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.