Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/32296
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Título : Neural Induction in Whole Chick Embryo Cultures by FGF
Autor : Álvarez, Ignacio S., Araujo, María, Nieto, M. Ángela
Fecha de publicación : 1-Jul-1998
Editor: Elsevier
Resumen: FGFs are well known as mesodermal inducers and they have been reported to have neural inducing and/or caudalizing activity inXenopus.To evaluate the role of FGFs in neural induction and patterning of the nervous system in chick embryos, we have targeted the ectopic expression of these factors by applying FGF-soaked beads to extended primitive streak chick embryos developing in culture. The whole embryo culture system allows to directly assessing the neural inducing activity on nonneural ectodermal cells. Our results show that FGFs induce the production of ectopic neural structures in the epiblast cell layer which are independent of the endogenous neural tube. The induced neural plates express several neural positional markers (Otx-2, Krox-20, EphA4, EphA7,andcHox-B9), although they lack anterior neural markers such asBF-1.These effects are very likely to be exerted by the direct action of FGF on epiblast cells because we have found no evidence of the induction of an organizer-like activity or of the presence of new axial mesoderm induced by the growth factor. We conclude that FGFs can act as direct neural inducers and that this action is exerted independently from the axial mesoderm.
Descripción : 13 páginas, 7 figuras, 1 tabla.
Versión del editor: http://dx.doi.org/10.1006/dbio.1998.8903
URI : http://hdl.handle.net/10261/32296
ISSN: 0925-4773
DOI: 10.1006/dbio.1998.8903
Citación : Mechanisms of Development 199(1): 42-54 (1998)
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