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Title

Control of cell behavior during vertebrate development by Slug, a zinc finger gene

AuthorsNieto, M. Ángela ; Sargent, Michael G.; Wilkinson, David G.; Cooke, J.
Issue Date6-May-1994
PublisherAmerican Association for the Advancement of Science
CitationScience 264(5160): 835-839 (1994)
AbstractSlug, a vertebrate gene encoding a zinc finger protein of the Snail family, is expressed in the neural crest and in mesodermal cells emigrating from the primitive streak. Early chick embryos were incubated with antisense oligonucleotides to chick Slug. These oligonucleotides specifically inhibit the normal change in cell behavior that occurs at the two sites in the emerging body plan in which the gene is expressed. This change, which is the transition from epithelial to mesenchymal character, occurs at the formation of mesoderm during gastrulation and on emigration of the neutral crest from the neural tube.
Description5 páginas.
Publisher version (URL)http://dx.doi.org/10.1126/science.7513443
URIhttp://hdl.handle.net/10261/32268
DOI10.1126/science.7513443
ISSN0036-8075
Appears in Collections:(IC) Artículos
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