Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/32234
Title: A receptor protein tyrosine kinase implicated in the segmental patterning of the hindbrain and mesoderm
Authors: Nieto, M. Ángela, Gilardi-Hebenstreit, Pascale, Charnay, Patrick, Wilkinson, David G.
Keywords: Segmentation
Rhombomeres
Somites, Mesoderm
CNS development
Neural crest
Receptor protein tyrosine kinase
Cell-cell interactions
Issue Date: Dec-1992
Publisher: Company of Biologists
Abstract: Pattern formation in the hindbrain and paraxial mesoderm of vertebrates occurs by the formation of a series of repeated segments. These processes of segmentation appear different at the morphological level, since hindbrain segments, the rhombomeres, form by the subdivision of the neural epithelium into compartments, whereas the mesodermal somites form by the sequential aggregation of mesenchymal cells into epithelial balls. Previous studies have implicated genes encoding transcription factors in the development of hindbrain segments, but nothing is known of genes involved in the formation of somites. Cellular interactions and signal transduction must be an important aspect of hindbrain segmentation, so we have screened for tyrosine kinases expressed in rhombomere-restricted patterns in the developing mouse embryo. We have identified a receptor protein tyrosine kinase, Sek, that has high relative levels of expression in rhombomeres 3 and 5. This alternating pattern is established coincidentally, both spatially and temporally, with the expression of Krox-20, a zinc-finger gene expressed prior to the morphological formation of rhombomeres. In addition, Sek expression occurs in several other developing tissues, including a dynamic regulation in the developing forebrain, spinal cord, early mesoderm and anterior presomitic mesoderm (segmental plate). The latter expression occurs in two stripes that correlate with, and presage, the formation of somites. Sek expression initially occurs throughout the presumptive somite, then becomes restricted anteriorly, and finally is down-regulated as the definitive somite is formed. These data suggest that despite the morphological differences in the segmentation of the hindbrain and mesoderm, Sek is involved in the segmental patterning of both of these tissues.
Description: 14 páginas, 9 figuras.
Publisher version (URL): http://dev.biologists.org/content/116/4/1137.abstract
URI: http://hdl.handle.net/10261/32234
ISSN: 0950-1991
Citation: Development 116(4): 1137-1150 (1992)
Appears in Collections:(IIBM) Artículos

Files in This Item:
File Description SizeFormat 
1137.full.pdf441,1 kBAdobe PDFView/Open
Show full item record
 
CSIC SFX LinksSFX Query

Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.