English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/32226
Share/Impact:
Statistics
logo share SHARE   Add this article to your Mendeley library MendeleyBASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Conserved segmental expression of Krox-20 in the vertebrate hindbrain and its relationship to lineage restriction

AuthorsNieto, M. Ángela ; Bradley, Leila C.; Wilkinson, David G.
KeywordsKrox-20
Segmentation
Hindbrain
Rhombomeres
Issue DateApr-1991
PublisherCompany of Biologists
CitationDevelopment 113(supl. 2): 59-62 (1991)
AbstractThe zinc-finger gene Krox-20 is expressed in two alternating segments, rhombomeres (r) 3 and 5, in the developing mouse hindbrain. This expression pattern is established prior to rhombomere formation in the mouse, but it is not known how the timing of expression relates to cellular events of segmentation, such as lineage restriction. We have cloned Krox-20 sequences from Xenopus and the chick and shown that its alternating expression pattern is conserved in these systems, suggesting that its role in hindbrain development is conserved. Analysis of the early stages of Krox-20 expression in the chick show that both domains of expression precede the restriction of cell lineage to specific rhombomeres, consistent with a role of this gene in early events of hindbrain segmentation. The finding that expression is not coincident with lineage restriction indicates that early expression may not reflect an irreversible commitment of cells to r3 and r5 and/or may be mosaic.
Description6 páginas, 4 figuras.
Publisher version (URL)http://dev.biologists.org/content/113/Supplement_2/59.abstract
URIhttp://hdl.handle.net/10261/32226
ISSN0950-1991
Appears in Collections:(IIBM) Artículos
Files in This Item:
File Description SizeFormat 
Krox-20_Nieto.pdf4,84 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.