English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/32225
Share/Impact:
Statistics
logo share SHARE   Add this article to your Mendeley library MendeleyBASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

DC FieldValueLanguage
dc.contributor.authorNieto, M. Ángela-
dc.contributor.authorGonzález, A.-
dc.contributor.authorLópez-Rivas, Abelardo-
dc.contributor.authorDíaz-Espada, F.-
dc.contributor.authorGambón, F.-
dc.date.accessioned2011-02-10T12:55:10Z-
dc.date.available2011-02-10T12:55:10Z-
dc.date.issued1990-09-
dc.identifier.citationJournal of Immunology 145(5): 1364-1368 (1990)es_ES
dc.identifier.issn0022-1767-
dc.identifier.urihttp://hdl.handle.net/10261/32225-
dc.description5 páginas.es_ES
dc.description.abstractIn recent years, several studies have confirmed the clonal elimination of thymocytes with receptors that recognize Ag and MHC molecules present on the membrane of thymic stromal cells, a process that may be relevant to the establishment of self-tolerance. In our work, we show that anti-CD3 treatment of single positive CD4+ or CD8+ human medullary thymocytes (obtained by anti-CD1a plus C) induces their apoptotic death. Some events commonly associated with the early steps of normal activation (IL-2R expression, increase in cytoplasmic Ca2+) are also induced after anti-CD3 treatment. Nevertheless, IL-2 is not secreted by these activated cells. The addition of exogenous IL-2 inhibits the apoptosis induced by anti-CD3. We suggest that the lack of secretion of IL-2 by medullary thymocytes may be a physiologic mechanism implicated in the process of negative selection that leads to tolerance.es_ES
dc.language.isoenges_ES
dc.publisherAmerican Association of Immunologistses_ES
dc.rightsclosedAccesses_ES
dc.titleIL-2 protects against anti-CD3-induced cell death in human medullary thymocyteses_ES
dc.typeartículoes_ES
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://www.jimmunol.org/content/145/5/1364.abstractes_ES
Appears in Collections:(IIBM) Artículos
Files in This Item:
There are no files associated with this item.
Show simple item record
 


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.