Please use this identifier to cite or link to this item:
|Title:||IL-2 protects T lymphocytes from glucocorticoid-induced DNA fragmentation and cell death|
|Authors:||Nieto, M. Ángela; López-Rivas, Abelardo|
|Publisher:||American Association of Immunologists|
|Citation:||Journal of Immunology 143(12): 4166-4170 (1989)|
|Abstract:||In the IL-2-dependent T cell clone CTLL-2, dexamethasone, a synthetic glucocorticoid, induces a suicide program characterized by the early degradation of chromatin in oligonucleosome-length fragments which precedes the loss of cell viability by 2 to 4 h. These effects are most likely mediated through the interaction with a specific glucocorticoid receptor as suggested by the structure-activity relationship of the various steroids tested. Incubation of nuclei of glucocorticoid- untreated cells in the presence of calcium and magnesium ions induces the cleavage of DNA in the linker region between nucleosomes, suggesting that fragmentation of chromatin in intact cells by glucocorticoids may involve the activation of a preexisting endonuclease. Interestingly, the presence of a saturating dose of IL-2 during the treatment of CTLL-2 cells with glucocorticoids completely blocks the cell death program.|
|Publisher version (URL):||http://www.jimmunol.org/content/143/12/4166.abstract|
|Appears in Collections:||(IIBM) Artículos|
Files in This Item:
There are no files associated with this item.
Show full item record
WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.