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Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/31868
Title: A functional leptin system is essential for sodium tungstate antiobesity action
Authors: Canals, Ignasi; Carmona, M. C.; Amigó, Marta; Barbera, Albert; Bortolozzi, Analía; Artigas, Francesc; Gomis, Ramon
Issue Date: 9-Oct-2008
Publisher: Endocrine Society
Citation: Endocrinology 150(2): 642-650 (2009)
Abstract: Sodium tungstate is a novel agent in the treatment of obesity. In diet-induced obese rats, it is able to reduce body weight gain by increasing energy expenditure. This study evaluated the role of leptin, a key regulator of energy homeostasis, in the tungstate antiobesity effect. Leptin receptordeficient Zucker fa/fa rats and leptin-deficient ob/ob mice were treated with tungstate. In lean animals, tungstate administration reducedbodyweight gainandfood intakeandincreased energy expenditure. However, in animals with deficiencies in the leptin system, treatment did not modify these parameters. In ob/ob mice in which leptin deficiency was restored through adipose tissue transplantation, treatment restored the tungstate-induced body weight gain and food intake reduction as well as energy expenditure increase. Furthermore, in animals in which tungstate administration increased energy expenditure, changes in the expression of key genes involved in brown adipose tissue thermogenesis were detected. Finally, the gene expression of the hypothalamic neuropeptides, Npy, Agrp, and Cart, involved in the leptin regulation of energy homeostasis, was also modified by tungstate in a leptin-dependent manner. In summary, the results indicate that the effectiveness of tungstate in reducing body weight gain is completely dependent on a functional leptin system.
Publisher version (URL): http://dx.doi.org/10.1210/en.2008-0881
URI: http://hdl.handle.net/10261/31868
ISSN: 0013-7227
DOI: 10.1210/en.2008-0881
E-ISSN: 1945-7170
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