English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/31549
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

A comparative study of age-related hearing loss in wild type and insulin-like growth factor I deficient mice

AuthorsRiquelme, Raquel; Cediel, Rafael ; Contreras, Julio ; Rodriguez-de la Rosa, Lourdes ; Murillo-Cuesta, Silvia ; Hernández-Sánchez, Catalina ; Zubeldia, José M. ; Cerdán, Sebastián ; Varela-Nieto, Isabel
KeywordsAging
Auditory brainstem responses
Deafness
Igf1-/- null mouse
Insuline-like factors
In vivo brain imaging
Presbycusis
Sensorineural deafness
Issue Date13-Jul-2010
PublisherFrontiers Media
CitationFrontiers in Neuroanatomy 4: 27 (2010)
AbstractInsulin-like growth factor-I (IGF-I) belongs to the family of insulin-related peptides that fulfils a key role during the late development of the nervous system. Human IGF1 mutations cause profound deafness, poor growth and mental retardation. Accordingly, Igf1(-/-) null mice are dwarfs that have low survival rates, cochlear alterations and severe sensorineural deafness. Presbycusis (age-related hearing loss) is a common disorder associated with aging that causes social and cognitive problems. Aging is also associated with a decrease in circulating IGF-I levels and this reduction has been related to cognitive and brain alterations, although there is no information as yet regarding the relationship between presbycusis and IGF-I biodisponibility. Here we present a longitudinal study of wild type Igf1(+/+) and null Igf1(-/-) mice from 2 to 12 months of age comparing the temporal progression of several parameters: hearing, brain morphology, cochlear cytoarchitecture, insulin-related factors and IGF gene expression and IGF-I serum levels. Complementary invasive and non-invasive techniques were used, including auditory brainstem-evoked response (ABR) recordings and in vivo MRI brain imaging. Igf1(-/-) null mice presented profound deafness at all the ages studied, without any obvious worsening of hearing parameters with aging. Igf1(+/+) wild type mice suffered significant age-related hearing loss, their auditory thresholds and peak I latencies augmenting as they aged, in parallel with a decrease in the circulating levels of IGF-I. Accordingly, there was an age-related spiral ganglion degeneration in wild type mice that was not evident in the Igf1 null mice. However, the Igf1(-/-) null mice in turn developed a prematurely aged stria vascularis reminiscent of the diabetic strial phenotype. Our data indicate that IGF-I is required for the correct development and maintenance of hearing, supporting the idea that IGF-I-based therapies could contribute to prevent or ameliorate age-related hearing loss.
Publisher version (URL)http://dx.doi.org/10.3389/fnana.2010.00027
URIhttp://hdl.handle.net/10261/31549
DOI10.3389/fnana.2010.00027
ISSN1662-5129
Appears in Collections:(IIBM) Artículos
(CIB) Artículos
Files in This Item:
File Description SizeFormat 
Frontiers in neuroanatomy 2010 vol4 art27 pp1.pdf2,98 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.