Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/31379
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dc.contributor.authorCasacuberta, Josep M.-
dc.contributor.authorVernhettes, Samantha-
dc.contributor.authorGrandbastien, Marie Angèle-
dc.date.accessioned2011-01-20T10:59:41Z-
dc.date.available2011-01-20T10:59:41Z-
dc.date.issued1995-06-01-
dc.identifier.citationEMBO Journal 14(11): 2670-2678 (1995)es_ES
dc.identifier.issn0261-4189-
dc.identifier.urihttp://hdl.handle.net/10261/31379-
dc.description9 pages, 5 figures, 2 tables.-- PMID: 7781619 [PubMed].-- PMCID: PMC398381.es_ES
dc.description.abstractRetroviruses consist of populations of different but closely related genomes referred to as quasispecies. A high mutation rate coupled with extremely rapid replication cycles allows these sequences to be highly interconnected in a rapid equilibrium. It is not known if other retroelements can show a similar population structure. We show here that when the tobacco Tnt1 retrotransposon is expressed, its RNA is not a unique sequence but a population of different but closely related sequences. Nevertheless, this highly variable population is not in a rapid equilibrium and could not be considered as a quasispecies. We have thus named the structure presented by Tnt1 RNA quasispecies-like. We show that the expression of Tnt1 in different situations gives rise to different populations of Tnt1 RNA sequences, suggesting an adaptive capacity for this element. The analysis of the variability within the total genomic population of Tnt1 elements shows that mutations frequently occur in important regulatory elements and that defective elements are often produced. We discuss the implications that this population structure could have for Tnt1 regulation and evolution.es_ES
dc.description.sponsorshipWe are extremely grateful to J.Gomez for suggesting that we should analyse Tntl variability and for very helpful discussions and useful comments on the manuscript. We thank H.Lucas, C.Robaglia and I.Small for critical reading of the manuscript. We also wish to thank A.Gabriel for sharing unpublished data with us. J.M.C. is supported by an INRA post-doctoral fellowship.es_ES
dc.language.isoenges_ES
dc.publisherNature Publishing Groupes_ES
dc.rightsclosedAccesses_ES
dc.subjectQuasispecieses_ES
dc.subjectRetrotransposones_ES
dc.subjectTobaccoes_ES
dc.subjectVariabilityes_ES
dc.titleSequence variability within the tobacco retrotransposon Tnt1 populationes_ES
dc.typeartículoes_ES
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC398381es_ES
dc.identifier.e-issn1460-2075-
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
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